A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells

Neoplastic events are marked by uncontrolled cell proliferation. One major focus of cancer research has been to identify treatments that reduce or inhibit cell growth. Over the years, various compounds, both naturally occurring and chemically synthesized, have been used to inhibit neoplastic cell pr...

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Veröffentlicht in:	British journal of cancer 1998-06, Vol.77 (12), p.2129-2137
Hauptverfasser:	Eck, KM, Yuan, L, Duffy, L, Ram, PT, Ayettey, S, Chen, I, Cohn, CS, Reed, JC, Hill, SM
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects bcl-2-Associated X Protein Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Northern Blotting, Western Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Chemotherapy DNA, Neoplasm - analysis DNA, Neoplasm - isolation & purification Drug Administration Schedule Drug Resistance Electrophoresis Epidemiology experimental-oncology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Melatonin - administration & dosage Molecular Medicine Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Oncology Pharmacology. Drug treatments Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-bcl-2 - biosynthesis Receptors, Estrogen - biosynthesis Receptors, Estrogen - drug effects Receptors, Estrogen - metabolism Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - metabolism Tretinoin - administration & dosage Tumor Cells, Cultured Tumors
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