Immortalisation of a human diploid fibroblast cell strain: a DT-diaphorase paradox

Transfection of a normal human diploid fibroblast cell strain, GM38, with a simian virus 40 (SV40) large T antigen containing plasmid, yielded an immortal cell line, G38-8X, which had a similar sensitivity as the parental cell strain to the quinone-containing chemotherapeutic agent mitomycin C (MMC)...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	British journal of cancer. Supplement 1996-07, Vol.27, p.S19-S22
Hauptverfasser:	Kuehl, B L, Brezden, C B, Traver, R D, Siegel, D, Ross, D, Renzing, J, Rauth, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Antigens, Polyomavirus Transforming - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - analysis Cell Line Cell Survival - drug effects Fibroblasts - drug effects Humans Mice Mitomycin - pharmacology NAD(P)H Dehydrogenase (Quinone) - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Radiation Tolerance Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!