The GPI-Phospholipase C of Trypanosoma brucei Is Nonessential but Influences Parasitemia in Mice

In the mammalian host, the cell surface of Trypanosoma brucei is protected by a variant surface glycoprotein that is anchored in the plasma membrane through covalent attachment of the COOH terminus to a glycosylphosphatidylinositol. The trypanosome also contains a phospholipase C (GPI-PLC) that clea...

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Veröffentlicht in:	The Journal of cell biology 1997-10, Vol.139 (1), p.103-114
Hauptverfasser:	Webb, Helena, Carnall, Nicola, Vanhamme, Luc, Rolin, Sylvie, Van Den Abbeele, Jakke, Welburn, Sue, Pays, Etienne, Carrington, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell lines Cellular biology Disease Models, Animal Enzymes Genes Glycosylphosphatidylinositols - genetics Glycosylphosphatidylinositols - physiology Infections Membrane glycoproteins Membranes Mice Mice, Inbred Strains Mutagenesis, Insertional Parasitemia Parasitemia - enzymology Parasitemia - genetics Parasitemia - parasitology Parasites Parasitism Phenotype Rodents Sequence Deletion Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - growth & development Trypanosome Trypanosomiasis, African - enzymology Trypanosomiasis, African - genetics Trypanosomiasis, African - parasitology Type C Phospholipases - biosynthesis Type C Phospholipases - genetics Type C Phospholipases - physiology
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