The life span of IgA plasma cells from the mouse intestine

Tritiated thymidine was injected during the neonatal period into conventional CBA mice. The disappearance rate of tritium-labeled IgA plasma cells was followed by a technique combining immunofluorescence with autoradiography which permitted the identification of the immunoglobulin class of plasma ce...

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Veröffentlicht in:	The Journal of experimental medicine 1973-08, Vol.138 (2), p.452-460
Hauptverfasser:	Mattioli, C A, Tomasi, Jr, T B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Fluorescent Antibody Technique Half-Life Immunoglobulin A Immunoglobulin G Immunoglobulin M Intestines - cytology Mice Mice, Inbred CBA Plasma Cells - metabolism Spleen - cytology Thymidine - metabolism Tritium
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container_title	The Journal of experimental medicine
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creator	Mattioli, C A Tomasi, Jr, T B
description	Tritiated thymidine was injected during the neonatal period into conventional CBA mice. The disappearance rate of tritium-labeled IgA plasma cells was followed by a technique combining immunofluorescence with autoradiography which permitted the identification of the immunoglobulin class of plasma cells with labeled nuclei. In this way, it was possible to calculate that the major population of intestinal IgA plasma cells have a half-life of 4.7 days under physiological conditions of stimulation. It was also found that the maximum life span of both intestinal IgA plasma cells and the IgA, IgG, and IgM plasma cells from the spleen is of the order of 7-8 wk.
doi_str_mv	10.1084/jem.138.2.452
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The disappearance rate of tritium-labeled IgA plasma cells was followed by a technique combining immunofluorescence with autoradiography which permitted the identification of the immunoglobulin class of plasma cells with labeled nuclei. In this way, it was possible to calculate that the major population of intestinal IgA plasma cells have a half-life of 4.7 days under physiological conditions of stimulation. 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The disappearance rate of tritium-labeled IgA plasma cells was followed by a technique combining immunofluorescence with autoradiography which permitted the identification of the immunoglobulin class of plasma cells with labeled nuclei. In this way, it was possible to calculate that the major population of intestinal IgA plasma cells have a half-life of 4.7 days under physiological conditions of stimulation. It was also found that the maximum life span of both intestinal IgA plasma cells and the IgA, IgG, and IgM plasma cells from the spleen is of the order of 7-8 wk.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Fluorescent Antibody Technique</subject><subject>Half-Life</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Intestines - cytology</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Plasma Cells - metabolism</subject><subject>Spleen - cytology</subject><subject>Thymidine - metabolism</subject><subject>Tritium</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkL1PwzAQxS0EKqEwMiJ5YkuwHTuxGZCqio9KlVjKbDm207pK4hCnSPz3uLSqYLrh_e7duwfALUYZRpw-bG2b4ZxnJKOMnIEEM4pSwXJ-DhKECEkxQuUluAphixCmlBUTMKGs5ESIBDyuNhY2rrYw9KqDvoaL9Qz2jQqtgto2TYD14Fs4Rqz1u2Ch60YbRtfZa3BRqybYm-Ocgo-X59X8LV2-vy7ms2WqKeVjamuBNFWkYoU2vwEws0ZzVmLKNWaFIKa0psBRKJVGUaq0oZhTTY2oTD4FTwfffle1cdN246Aa2Q-uVcO39MrJ_0rnNnLtvyTBuaCIRYP7o8HgP3cxvGxd2P-mOhtfkhyLsiCMRzA9gHrwIQy2Ph3BSO7LlrFsGcuWRMayI3_3N9mJPrab_wC7dHsL</recordid><startdate>19730801</startdate><enddate>19730801</enddate><creator>Mattioli, C A</creator><creator>Tomasi, Jr, T B</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19730801</creationdate><title>The life span of IgA plasma cells from the mouse intestine</title><author>Mattioli, C A ; Tomasi, Jr, T B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-ef90c4a2b56cd0144515edc857148c15692d7ed614517ac0dc8bcd4184c4d9bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Fluorescent Antibody Technique</topic><topic>Half-Life</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Intestines - cytology</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Plasma Cells - metabolism</topic><topic>Spleen - cytology</topic><topic>Thymidine - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mattioli, C A</creatorcontrib><creatorcontrib>Tomasi, Jr, T B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mattioli, C A</au><au>Tomasi, Jr, T B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The life span of IgA plasma cells from the mouse intestine</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1973-08-01</date><risdate>1973</risdate><volume>138</volume><issue>2</issue><spage>452</spage><epage>460</epage><pages>452-460</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Tritiated thymidine was injected during the neonatal period into conventional CBA mice. 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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Animals Autoradiography Fluorescent Antibody Technique Half-Life Immunoglobulin A Immunoglobulin G Immunoglobulin M Intestines - cytology Mice Mice, Inbred CBA Plasma Cells - metabolism Spleen - cytology Thymidine - metabolism Tritium
title	The life span of IgA plasma cells from the mouse intestine
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