Quantitative investigations of idiotypic antibodies. V. Factors affecting the persistence and replacement of clones of antibody-producing cells

The effect of challenge by antigen on persistence of clones of antibody-producing cells and on the induction of new clones was investigated through quantitative measurements of idiotypic specificities. In each of nine rabbits idiotypic specificities present in the earliest bleedings were completely...

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Veröffentlicht in:	The Journal of experimental medicine 1971-09, Vol.134 (3 Pt 1), p.765-785
Hauptverfasser:	Spring, S B, Schroeder, K W, Nisonoff, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody-Producing Cells - physiology Dose-Response Relationship, Immunologic Immunization Immunoglobulin Fab Fragments - metabolism Immunoglobulin Idiotypes - immunology Rabbits
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