Macrophage-digested antigen as inducer of delayed hypersensitivity
Sheep erythrocytes ingested by guinea pig peritoneal macrophages in vitro, and permitted to undergo digestion for various periods, were found after some hours to lose the capacity to induce antibodies while gaining the ability to invoke delayed hypersensitivity. These observations may be related to...
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| Veröffentlicht in: | The Journal of experimental medicine 1971-03, Vol.133 (3), p.494-505 |
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| container_title | The Journal of experimental medicine |
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| creator | Pearson, M N Raffel, S |
| description | Sheep erythrocytes ingested by guinea pig peritoneal macrophages in vitro, and permitted to undergo digestion for various periods, were found after some hours to lose the capacity to induce antibodies while gaining the ability to invoke delayed hypersensitivity. These observations may be related to the known predilection of small molecular immunogens to act as good inducers of delayed reactivity and poor stimulators of antibody. They may be related also to the activity of mycobacterial adjuvant as a vehicle for the induction of delayed hypersensitivity on the basis that this melange activates macrophages to phagocytose and enzymatically degrade macromolecular antigens rapidly. The thesis that small fragments of antigenic molecules may preferentially invoke hypersensitivity can be interpreted on the basis of current concepts of multicellular involvements in immune responses. |
| doi_str_mv | 10.1084/jem.133.3.494 |
| format | Article |
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These observations may be related to the known predilection of small molecular immunogens to act as good inducers of delayed reactivity and poor stimulators of antibody. They may be related also to the activity of mycobacterial adjuvant as a vehicle for the induction of delayed hypersensitivity on the basis that this melange activates macrophages to phagocytose and enzymatically degrade macromolecular antigens rapidly. 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The thesis that small fragments of antigenic molecules may preferentially invoke hypersensitivity can be interpreted on the basis of current concepts of multicellular involvements in immune responses.</description><subject>Animals</subject><subject>Antigens</subject><subject>Erythrocytes - immunology</subject><subject>Female</subject><subject>Freund's Adjuvant</subject><subject>Guinea Pigs</subject><subject>Hemagglutination Tests</subject><subject>Hypersensitivity, Delayed - etiology</subject><subject>In Vitro Techniques</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Peritoneum - cytology</subject><subject>Phagocytosis</subject><subject>Sheep</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEQhoMotVaPHoU9edua7GSz2YugxS-oeNFzSLOTNmW_3OwW9t8baSl6moF5eGfmIeSa0Tmjkt9tsZozgDnMec5PyJSlnMZ5CvKUTClNkphRmp2TC--3lDLOUzEhk5QxxiGfksd3bbqm3eg1xoVbo--xiHTdh7aOtI9cXQwGu6ixUYGlHsN0M7bYeay9693O9eMlObO69Hh1qDPy9fz0uXiNlx8vb4uHZWw4l30MgufSgE2FQMFpjllmACC1NGUaeSYRuORa2mxVcJEjZSvGbJHlYK0wmYAZud_ntsOqwsJg3Xe6VG3nKt2NqtFO_Z_UbqPWzU4lDGQQEgJuDwFd8z2EV1XlvMGy1DU2g1cyOKGJ5AGM92BQ432H9riEUfUrXQXpKkhXoIL0wN_8vexIHyzDD175fpY</recordid><startdate>19710301</startdate><enddate>19710301</enddate><creator>Pearson, M N</creator><creator>Raffel, S</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19710301</creationdate><title>Macrophage-digested antigen as inducer of delayed hypersensitivity</title><author>Pearson, M N ; Raffel, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-36498c3f566e6409e77c3335f051ae478e3484a8f7bd469e01b11fd793ff6c763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Erythrocytes - immunology</topic><topic>Female</topic><topic>Freund's Adjuvant</topic><topic>Guinea Pigs</topic><topic>Hemagglutination Tests</topic><topic>Hypersensitivity, Delayed - etiology</topic><topic>In Vitro Techniques</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Peritoneum - cytology</topic><topic>Phagocytosis</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pearson, M N</creatorcontrib><creatorcontrib>Raffel, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pearson, M N</au><au>Raffel, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrophage-digested antigen as inducer of delayed hypersensitivity</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1971-03-01</date><risdate>1971</risdate><volume>133</volume><issue>3</issue><spage>494</spage><epage>505</epage><pages>494-505</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Sheep erythrocytes ingested by guinea pig peritoneal macrophages in vitro, and permitted to undergo digestion for various periods, were found after some hours to lose the capacity to induce antibodies while gaining the ability to invoke delayed hypersensitivity. 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| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1971-03, Vol.133 (3), p.494-505 |
| issn | 0022-1007 1540-9538 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antigens Erythrocytes - immunology Female Freund's Adjuvant Guinea Pigs Hemagglutination Tests Hypersensitivity, Delayed - etiology In Vitro Techniques Macrophages - immunology Male Peritoneum - cytology Phagocytosis Sheep |
| title | Macrophage-digested antigen as inducer of delayed hypersensitivity |
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