Requirement of the MRN complex for ATM activation by DNA damage

The ATM protein kinase is a primary activator of the cellular response to DNA double‐strand breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in various branches of the DNA damage response network. ATM deficiency causes the genetic disorder ataxia‐telangiectasia (A‐...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The EMBO journal 2003-10, Vol.22 (20), p.5612-5621
Hauptverfasser:	Uziel, Tamar, Lerenthal, Yaniv, Moyal, Lilach, Andegeko, Yair, Mittelman, Leonid, Shiloh, Yosef
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia - genetics Ataxia Telangiectasia - pathology Ataxia Telangiectasia Mutated Proteins ataxia-telangiectasia ATM ATM protein Cell Cycle Proteins - genetics Cell Line Cell Survival Deoxyribonucleic acid DNA DNA Damage DNA damage response DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics double-strand breaks EMBO13 Gene Expression Regulation Humans MRE11 gene MRE11 Homologue Protein MRN complex NBS1 gene Nijmegen breakage syndrome Nuclear Proteins - deficiency Nuclear Proteins - genetics Phosphorylation Protein-Serine-Threonine Kinases - genetics Rad50 protein Reference Values Saccharomyces cerevisiae Proteins - genetics Tumor Suppressor Proteins
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!