IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung

Interleukin (IL) 31Ralpha (glycoprotein 130-like monocyte receptor and glycoprotein 130-like receptor) heterodimerizes with oncostatin M receptor beta to bind IL-31, a cytokine expressed preferentially by CD4(+) T helper type 2 (Th2) cells. However, the functions of IL-31-IL-31R signaling in immune...

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Veröffentlicht in:	The Journal of experimental medicine 2007-03, Vol.204 (3), p.481-487
Hauptverfasser:	Perrigoue, Jacqueline G, Li, Ji, Zaph, Colby, Goldschmidt, Michael, Scott, Phillip, de Sauvage, Frederic J, Pearce, Edward J, Ghilardi, Nico, Artis, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Brief Definitive Reports Cells, Cultured Coculture Techniques Down-Regulation - genetics Down-Regulation - immunology Inflammation Mediators - metabolism Inflammation Mediators - physiology Interleukins - metabolism Lung Diseases, Parasitic - immunology Lung Diseases, Parasitic - pathology Lung Diseases, Parasitic - prevention & control Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Receptors, Interleukin - genetics Receptors, Interleukin - metabolism Receptors, Interleukin - physiology Schistosoma mansoni Schistosomiasis mansoni - genetics Schistosomiasis mansoni - immunology Schistosomiasis mansoni - pathology Th2 Cells - immunology Th2 Cells - pathology
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