THE APPEARANCE OF A HEPATOTROPHIC VIRUS IN MICE THYMECTOMIZED AT BIRTH
Inbred (C57BL; C3H/Bi), hybrid (C57BL x C3H/Bi), and outbred (TO) mice thymectomized within 24 hours of birth develop wasting symptoms and die prematurely and a proportion of these animals have pathological changes in the liver. The incidence of the liver lesions varies according to the strain of mi...
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| Veröffentlicht in: | The Journal of experimental medicine 1963-12, Vol.118 (6), p.1069-1082 |
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| container_title | The Journal of experimental medicine |
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| creator | EAST, J PARROTT, D M CHESTERMAN, F C POMERANCE, A |
| description | Inbred (C57BL; C3H/Bi), hybrid (C57BL x C3H/Bi), and outbred (TO) mice thymectomized within 24 hours of birth develop wasting symptoms and die prematurely and a proportion of these animals have pathological changes in the liver. The incidence of the liver lesions varies according to the strain of mice used and the lesions tend to occur in animals dying comparatively late. These lesions were shown, by passage of tissue suspensions and of cell-free liver extracts, to be due to a hepatotrophic virus probably mouse hepatitis virus-1 (MHV-1). The part played by the hepatotrophic virus in the premature death of thymectomized mice is discussed but, although neonatal thymectomy apparently alters a normally stable host-virus relationship, it is not thought that the virus is primarily responsible for the death of its host. The role of this virus in the production of the physical wasting is also considered to be problematic. |
| doi_str_mv | 10.1084/jem.118.6.1069 |
| format | Article |
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The incidence of the liver lesions varies according to the strain of mice used and the lesions tend to occur in animals dying comparatively late. These lesions were shown, by passage of tissue suspensions and of cell-free liver extracts, to be due to a hepatotrophic virus probably mouse hepatitis virus-1 (MHV-1). The part played by the hepatotrophic virus in the premature death of thymectomized mice is discussed but, although neonatal thymectomy apparently alters a normally stable host-virus relationship, it is not thought that the virus is primarily responsible for the death of its host. The role of this virus in the production of the physical wasting is also considered to be problematic.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.118.6.1069</identifier><identifier>PMID: 14112266</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; Animals, Newborn ; Cachexia ; Hepatitis Viruses ; Liver ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Old Medline ; Pathology ; Physiology ; Thymectomy ; Thymus Gland</subject><ispartof>The Journal of experimental medicine, 1963-12, Vol.118 (6), p.1069-1082</ispartof><rights>Copyright © 1963, by The Rockefeller Institute</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-2cfdb254833a3a6fe493255e1d362ac97ecae94b0e7cbac3f63237a325f936c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14112266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EAST, J</creatorcontrib><creatorcontrib>PARROTT, D M</creatorcontrib><creatorcontrib>CHESTERMAN, F C</creatorcontrib><creatorcontrib>POMERANCE, A</creatorcontrib><title>THE APPEARANCE OF A HEPATOTROPHIC VIRUS IN MICE THYMECTOMIZED AT BIRTH</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Inbred (C57BL; C3H/Bi), hybrid (C57BL x C3H/Bi), and outbred (TO) mice thymectomized within 24 hours of birth develop wasting symptoms and die prematurely and a proportion of these animals have pathological changes in the liver. The incidence of the liver lesions varies according to the strain of mice used and the lesions tend to occur in animals dying comparatively late. These lesions were shown, by passage of tissue suspensions and of cell-free liver extracts, to be due to a hepatotrophic virus probably mouse hepatitis virus-1 (MHV-1). The part played by the hepatotrophic virus in the premature death of thymectomized mice is discussed but, although neonatal thymectomy apparently alters a normally stable host-virus relationship, it is not thought that the virus is primarily responsible for the death of its host. The role of this virus in the production of the physical wasting is also considered to be problematic.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cachexia</subject><subject>Hepatitis Viruses</subject><subject>Liver</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Old Medline</subject><subject>Pathology</subject><subject>Physiology</subject><subject>Thymectomy</subject><subject>Thymus Gland</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Pg0AQhjdGY2v16tHsyRu4XyxwMUGkQtIWgtREL5tluyiGlsq2Jv57adr4cZpM5pl3Jg8AlxjZGHns5l0vbYw9m_ct94_AEDsMWb5DvWMwRIgQCyPkDsCZMe8IYcYcfgoGmGFMCOdDMC7iCAZZFgV5MAsjmI5hAOMoC4q0yNMsTkL4lOTzR5jM4DTpgSJ-nkZhkU6Tl-geBgW8S_IiPgcnlWyMvjjUEZiPoyKMrUn6kITBxFLU8zYWUdWiJA7zKJVU8koznxLH0XhBOZHKd7WS2mcl0q4qpaIVp4S6smcqn3JF6Qjc7nPX23KpF0qvNp1sxLqrl7L7Eq2sxf_Jqn4Tr-2nIJi63PP7gOtDQNd-bLXZiGVtlG4audLt1giPMtdxXdSD9h5UXWtMp6ufIxiJnXrRqxe9esHFTn2_cPX3tV_84Jp-Awymed8</recordid><startdate>19631201</startdate><enddate>19631201</enddate><creator>EAST, J</creator><creator>PARROTT, D M</creator><creator>CHESTERMAN, F C</creator><creator>POMERANCE, A</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19631201</creationdate><title>THE APPEARANCE OF A HEPATOTROPHIC VIRUS IN MICE THYMECTOMIZED AT BIRTH</title><author>EAST, J ; PARROTT, D M ; CHESTERMAN, F C ; POMERANCE, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-2cfdb254833a3a6fe493255e1d362ac97ecae94b0e7cbac3f63237a325f936c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Cachexia</topic><topic>Hepatitis Viruses</topic><topic>Liver</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Old Medline</topic><topic>Pathology</topic><topic>Physiology</topic><topic>Thymectomy</topic><topic>Thymus Gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EAST, J</creatorcontrib><creatorcontrib>PARROTT, D M</creatorcontrib><creatorcontrib>CHESTERMAN, F C</creatorcontrib><creatorcontrib>POMERANCE, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EAST, J</au><au>PARROTT, D M</au><au>CHESTERMAN, F C</au><au>POMERANCE, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE APPEARANCE OF A HEPATOTROPHIC VIRUS IN MICE THYMECTOMIZED AT BIRTH</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1963-12-01</date><risdate>1963</risdate><volume>118</volume><issue>6</issue><spage>1069</spage><epage>1082</epage><pages>1069-1082</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Inbred (C57BL; C3H/Bi), hybrid (C57BL x C3H/Bi), and outbred (TO) mice thymectomized within 24 hours of birth develop wasting symptoms and die prematurely and a proportion of these animals have pathological changes in the liver. The incidence of the liver lesions varies according to the strain of mice used and the lesions tend to occur in animals dying comparatively late. These lesions were shown, by passage of tissue suspensions and of cell-free liver extracts, to be due to a hepatotrophic virus probably mouse hepatitis virus-1 (MHV-1). The part played by the hepatotrophic virus in the premature death of thymectomized mice is discussed but, although neonatal thymectomy apparently alters a normally stable host-virus relationship, it is not thought that the virus is primarily responsible for the death of its host. The role of this virus in the production of the physical wasting is also considered to be problematic.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>14112266</pmid><doi>10.1084/jem.118.6.1069</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1963-12, Vol.118 (6), p.1069-1082 |
| issn | 0022-1007 1540-9538 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Animals, Newborn Cachexia Hepatitis Viruses Liver Mice Mice, Inbred C3H Mice, Inbred C57BL Old Medline Pathology Physiology Thymectomy Thymus Gland |
| title | THE APPEARANCE OF A HEPATOTROPHIC VIRUS IN MICE THYMECTOMIZED AT BIRTH |
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