Endotoxin fever in granulocytopenic animals
The febrile response to bacterial endotoxin was measured in rabbits made leukopenic with nitrogen mustard. A striking increase in susceptibility to the lethal effects of endotoxin occurred in severely leukopenic animals. Animals without circulating granulocytes, or with only basophils, developed no...
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Veröffentlicht in: | The Journal of experimental medicine 1961-06, Vol.113 (6), p.1115-1125 |
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description | The febrile response to bacterial endotoxin was measured in rabbits made leukopenic with nitrogen mustard. A striking increase in susceptibility to the lethal effects of endotoxin occurred in severely leukopenic animals. Animals without circulating granulocytes, or with only basophils, developed no significant fever after endotoxin injection. Animals with circulating granulocytes other than basophils exhibited a biphasic febrile response to endotoxin; this response was significantly less in magnitude than that of control animals. Control animals, severely granulocytopenic animals, and animals with no circulating granulocytes other than basophils showed comparable febrile responses to serum pyrogen. These results suggest that granulocytes inactivate endotoxin in vivo and support the hypothesis that leukocyte pyrogen is a necessary intermediate in endotoxin fever. Basophils do not appear to participate in this process. These observations also contradict previous studies that were taken to indicate a normal febrile response to endotoxin in leukopenic animals and suggest that those results are related to the persistence of granulocytes. |
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A striking increase in susceptibility to the lethal effects of endotoxin occurred in severely leukopenic animals. Animals without circulating granulocytes, or with only basophils, developed no significant fever after endotoxin injection. Animals with circulating granulocytes other than basophils exhibited a biphasic febrile response to endotoxin; this response was significantly less in magnitude than that of control animals. Control animals, severely granulocytopenic animals, and animals with no circulating granulocytes other than basophils showed comparable febrile responses to serum pyrogen. These results suggest that granulocytes inactivate endotoxin in vivo and support the hypothesis that leukocyte pyrogen is a necessary intermediate in endotoxin fever. Basophils do not appear to participate in this process. These observations also contradict previous studies that were taken to indicate a normal febrile response to endotoxin in leukopenic animals and suggest that those results are related to the persistence of granulocytes.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.113.6.1115</identifier><identifier>PMID: 13713584</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Agranulocytosis ; Animals ; Antitoxins - pharmacology ; Endotoxins ; Fever ; Interleukin-1 ; Leukocyte Count ; Leukopenia ; Old Medline ; Rabbits ; Toxins, Biological - pharmacology</subject><ispartof>The Journal of experimental medicine, 1961-06, Vol.113 (6), p.1115-1125</ispartof><rights>Copyright © Copyright, 1961, by The Rockefeller Institute</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-4f27c64fedd7a7f1c01ef1581b4d8ae1fbfea5cca6e7f58905278d0a42b62a2d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13713584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HERION, J C</creatorcontrib><creatorcontrib>WALKER, R I</creatorcontrib><creatorcontrib>PALMER, J G</creatorcontrib><title>Endotoxin fever in granulocytopenic animals</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>The febrile response to bacterial endotoxin was measured in rabbits made leukopenic with nitrogen mustard. A striking increase in susceptibility to the lethal effects of endotoxin occurred in severely leukopenic animals. Animals without circulating granulocytes, or with only basophils, developed no significant fever after endotoxin injection. Animals with circulating granulocytes other than basophils exhibited a biphasic febrile response to endotoxin; this response was significantly less in magnitude than that of control animals. Control animals, severely granulocytopenic animals, and animals with no circulating granulocytes other than basophils showed comparable febrile responses to serum pyrogen. These results suggest that granulocytes inactivate endotoxin in vivo and support the hypothesis that leukocyte pyrogen is a necessary intermediate in endotoxin fever. Basophils do not appear to participate in this process. These observations also contradict previous studies that were taken to indicate a normal febrile response to endotoxin in leukopenic animals and suggest that those results are related to the persistence of granulocytes.</description><subject>Agranulocytosis</subject><subject>Animals</subject><subject>Antitoxins - pharmacology</subject><subject>Endotoxins</subject><subject>Fever</subject><subject>Interleukin-1</subject><subject>Leukocyte Count</subject><subject>Leukopenia</subject><subject>Old Medline</subject><subject>Rabbits</subject><subject>Toxins, Biological - pharmacology</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1961</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1PwzAMhiMEYmNw5Yh24oJa4jRpsgsSmsaHNIkLnKM0TUanNhlJi9i_J9MmPi62Jb9-bT8IXQLOAQt6uzZdDlDkZYrAjtAYGMXZjBXiGI0xJiQDjPkIncW4xhgoZeUpGkHBoWCCjtHNwtW-91-Nm1rzacI0Faug3NB6ve39xrhGT5VrOtXGc3RiUzIXhzxBbw-L1_lTtnx5fJ7fLzNdCNFn1BKuS2pNXXPFLWgMxgITUNFaKAO2skYxrVVpuGVihhnhosaKkqokitTFBN3tfTdD1ZlaG9cH1cpNSFeErfSqkf87rnmXK_8pSfqLEpIMrg8GwX8MJvaya6I2bauc8UOUgnA6oyCSMN8LdfAxBmN_lgCWO74y8ZWJryzljm8auPp72q_8ALT4Bpb1eGA</recordid><startdate>19610601</startdate><enddate>19610601</enddate><creator>HERION, J C</creator><creator>WALKER, R I</creator><creator>PALMER, J G</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19610601</creationdate><title>Endotoxin fever in granulocytopenic animals</title><author>HERION, J C ; WALKER, R I ; PALMER, J G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-4f27c64fedd7a7f1c01ef1581b4d8ae1fbfea5cca6e7f58905278d0a42b62a2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1961</creationdate><topic>Agranulocytosis</topic><topic>Animals</topic><topic>Antitoxins - pharmacology</topic><topic>Endotoxins</topic><topic>Fever</topic><topic>Interleukin-1</topic><topic>Leukocyte Count</topic><topic>Leukopenia</topic><topic>Old Medline</topic><topic>Rabbits</topic><topic>Toxins, Biological - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HERION, J C</creatorcontrib><creatorcontrib>WALKER, R I</creatorcontrib><creatorcontrib>PALMER, J G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HERION, J C</au><au>WALKER, R I</au><au>PALMER, J G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endotoxin fever in granulocytopenic animals</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1961-06-01</date><risdate>1961</risdate><volume>113</volume><issue>6</issue><spage>1115</spage><epage>1125</epage><pages>1115-1125</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>The febrile response to bacterial endotoxin was measured in rabbits made leukopenic with nitrogen mustard. A striking increase in susceptibility to the lethal effects of endotoxin occurred in severely leukopenic animals. Animals without circulating granulocytes, or with only basophils, developed no significant fever after endotoxin injection. Animals with circulating granulocytes other than basophils exhibited a biphasic febrile response to endotoxin; this response was significantly less in magnitude than that of control animals. Control animals, severely granulocytopenic animals, and animals with no circulating granulocytes other than basophils showed comparable febrile responses to serum pyrogen. These results suggest that granulocytes inactivate endotoxin in vivo and support the hypothesis that leukocyte pyrogen is a necessary intermediate in endotoxin fever. Basophils do not appear to participate in this process. These observations also contradict previous studies that were taken to indicate a normal febrile response to endotoxin in leukopenic animals and suggest that those results are related to the persistence of granulocytes.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>13713584</pmid><doi>10.1084/jem.113.6.1115</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Agranulocytosis Animals Antitoxins - pharmacology Endotoxins Fever Interleukin-1 Leukocyte Count Leukopenia Old Medline Rabbits Toxins, Biological - pharmacology |
title | Endotoxin fever in granulocytopenic animals |
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