Association of Thyroid Hormone Concentrations with Levels of Organochlorine Compounds in Cord Blood of Neonates
Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and...
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| Veröffentlicht in: | Environmental health perspectives 2007-12, Vol.115 (12), p.1780-1786 |
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| creator | Maervoet, Johan Griet Vermeir Covaci, Adrian Nicolas Van Larebeke Koppen, Gudrun Schoeters, Greet Nelen, Vera Baeyens, Willy Schepens, Paul Maria K. Viaene |
| description | Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organochlorine compounds such as polychlorinated biphenyls (PCBs) and dioxins, can interfere with thyroid hormone homeostasis. Whether these contaminants can affect circulating levels of thyroid hormones in humans is unclear, however, because the results of available studies are inconsistent. /// The aim of the present study is to examine the possible relationships between concentrations of environmental pollutants and thyroid hormone levels in human umbilical cord blood. /// We measured concentrations of environmental pollutants [including selected PCBs, dioxin-like compounds, hexachlorobenzene, p,p'-DDE (dichlorodiphenyldichloroethylene), cadmium, lead] and thyroid hormones in the cord blood of 198 neonates. /// A statistically significant inverse relationship between concentrations of organochlorine compounds and levels of both free triiodothyronine (fT₃) and free thyroxine (fT₄), but not thyroid-stimulating hormone, was observed. We found no association between concentrations of heavy metals and thyroid hormone levels. /// Our results suggest that environmental chemicals may affect the thyroid system of human neonates. Although the differences in fT₃ and fF₄ levels associated with the organochlorine compounds were within the normal range, the observed interferences may still have detrimental effects on the neurologic development of the individual children, given the importance of thyroid hormones in brain development. |
| doi_str_mv | 10.1289/ehp.10486 |
| format | Article |
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Viaene</creator><creatorcontrib>Maervoet, Johan ; Griet Vermeir ; Covaci, Adrian ; Nicolas Van Larebeke ; Koppen, Gudrun ; Schoeters, Greet ; Nelen, Vera ; Baeyens, Willy ; Schepens, Paul ; Maria K. Viaene</creatorcontrib><description>Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organochlorine compounds such as polychlorinated biphenyls (PCBs) and dioxins, can interfere with thyroid hormone homeostasis. Whether these contaminants can affect circulating levels of thyroid hormones in humans is unclear, however, because the results of available studies are inconsistent. /// The aim of the present study is to examine the possible relationships between concentrations of environmental pollutants and thyroid hormone levels in human umbilical cord blood. /// We measured concentrations of environmental pollutants [including selected PCBs, dioxin-like compounds, hexachlorobenzene, p,p'-DDE (dichlorodiphenyldichloroethylene), cadmium, lead] and thyroid hormones in the cord blood of 198 neonates. /// A statistically significant inverse relationship between concentrations of organochlorine compounds and levels of both free triiodothyronine (fT₃) and free thyroxine (fT₄), but not thyroid-stimulating hormone, was observed. We found no association between concentrations of heavy metals and thyroid hormone levels. /// Our results suggest that environmental chemicals may affect the thyroid system of human neonates. Although the differences in fT₃ and fF₄ levels associated with the organochlorine compounds were within the normal range, the observed interferences may still have detrimental effects on the neurologic development of the individual children, given the importance of thyroid hormones in brain development.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.10486</identifier><identifier>PMID: 18087600</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Adult ; Blood ; Blood plasma ; Chemical hazards ; Chidren's Health ; Chlorinated hydrocarbons ; Cord blood ; Environmental health ; Environmental Pollutants - blood ; Female ; Fetal blood ; Fetal Blood - chemistry ; Health aspects ; Humans ; Hydrocarbons, Chlorinated - blood ; Infant, Newborn ; Infants ; Organochlorine compounds ; Polychlorinated biphenyls ; Pregnancy ; Regression Analysis ; Thyroid hormones ; Thyroid Hormones - blood</subject><ispartof>Environmental health perspectives, 2007-12, Vol.115 (12), p.1780-1786</ispartof><rights>Copyright 2007</rights><rights>COPYRIGHT 2007 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Dec 2007</rights><rights>2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c718t-b0e66f1c28570647ac590439d21b11d40efb07ae42e89dc8c3c7d2a3aa81777b3</citedby><cites>FETCH-LOGICAL-c718t-b0e66f1c28570647ac590439d21b11d40efb07ae42e89dc8c3c7d2a3aa81777b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4540030$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4540030$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,864,885,27923,27924,53790,53792,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18087600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maervoet, Johan</creatorcontrib><creatorcontrib>Griet Vermeir</creatorcontrib><creatorcontrib>Covaci, Adrian</creatorcontrib><creatorcontrib>Nicolas Van Larebeke</creatorcontrib><creatorcontrib>Koppen, Gudrun</creatorcontrib><creatorcontrib>Schoeters, Greet</creatorcontrib><creatorcontrib>Nelen, Vera</creatorcontrib><creatorcontrib>Baeyens, Willy</creatorcontrib><creatorcontrib>Schepens, Paul</creatorcontrib><creatorcontrib>Maria K. Viaene</creatorcontrib><title>Association of Thyroid Hormone Concentrations with Levels of Organochlorine Compounds in Cord Blood of Neonates</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organochlorine compounds such as polychlorinated biphenyls (PCBs) and dioxins, can interfere with thyroid hormone homeostasis. Whether these contaminants can affect circulating levels of thyroid hormones in humans is unclear, however, because the results of available studies are inconsistent. /// The aim of the present study is to examine the possible relationships between concentrations of environmental pollutants and thyroid hormone levels in human umbilical cord blood. /// We measured concentrations of environmental pollutants [including selected PCBs, dioxin-like compounds, hexachlorobenzene, p,p'-DDE (dichlorodiphenyldichloroethylene), cadmium, lead] and thyroid hormones in the cord blood of 198 neonates. /// A statistically significant inverse relationship between concentrations of organochlorine compounds and levels of both free triiodothyronine (fT₃) and free thyroxine (fT₄), but not thyroid-stimulating hormone, was observed. We found no association between concentrations of heavy metals and thyroid hormone levels. /// Our results suggest that environmental chemicals may affect the thyroid system of human neonates. Although the differences in fT₃ and fF₄ levels associated with the organochlorine compounds were within the normal range, the observed interferences may still have detrimental effects on the neurologic development of the individual children, given the importance of thyroid hormones in brain development.</description><subject>Adult</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Chemical hazards</subject><subject>Chidren's Health</subject><subject>Chlorinated hydrocarbons</subject><subject>Cord blood</subject><subject>Environmental health</subject><subject>Environmental Pollutants - blood</subject><subject>Female</subject><subject>Fetal blood</subject><subject>Fetal Blood - chemistry</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hydrocarbons, Chlorinated - blood</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Organochlorine compounds</subject><subject>Polychlorinated biphenyls</subject><subject>Pregnancy</subject><subject>Regression Analysis</subject><subject>Thyroid hormones</subject><subject>Thyroid Hormones - blood</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0s9v0zAUB_AIgVgZHLgjFHGYxCHFdhLbuSCVCtikikowuFqu89K4Sv2KnQz23-P-0FhRJaYcotgfP-vlfZPkJSVjymT1DtrNmJJC8kfJiJYly6qKFY-TESEVzbjg5VnyLIQVIYRKzp8mZ1QSKTghowQnIaCxurfoUmzS6_bWo63TS_RrdJBO0Rlwvd-BkP6yfZvO4Aa6sNVzv9QOTduhtzu83uDg6pBaFz98nX7oEOut_ALodA_hefKk0V2AF4f3efL908fr6WU2m3--mk5mmRFU9tmCAOcNNUyWgvBCaFNWpMirmtEFpXVBoFkQoaFgIKvaSJMbUTOday2pEGKRnyfv93U3w2IN9b6HTm28XWt_q1BbdbzjbKuWeKMYzQWlRSxwcSjg8ecAoVdrGwx0nXaAQ4iOFVxUD4CkJBWn4r-QFjKPY5ERvvkHrnDwLv4uxRjjlJdse222R0vdgbKuwdiGWYKD2E2cXGPj8iReK2JEJIl-fMLHp4a1NScPvD06EE0Pv_ulHkJQV9--PtzOfxzbi3u2Bd31bcBu2AXsZFHjMQQPzd30KFHb3KuYe7XLfbSv74_7rzwEPYJXe7AKPfq7_aIs4ibJ_wAmTgTj</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Maervoet, Johan</creator><creator>Griet Vermeir</creator><creator>Covaci, Adrian</creator><creator>Nicolas Van Larebeke</creator><creator>Koppen, Gudrun</creator><creator>Schoeters, Greet</creator><creator>Nelen, Vera</creator><creator>Baeyens, Willy</creator><creator>Schepens, Paul</creator><creator>Maria K. 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Viaene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Thyroid Hormone Concentrations with Levels of Organochlorine Compounds in Cord Blood of Neonates</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>115</volume><issue>12</issue><spage>1780</spage><epage>1786</epage><pages>1780-1786</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organochlorine compounds such as polychlorinated biphenyls (PCBs) and dioxins, can interfere with thyroid hormone homeostasis. Whether these contaminants can affect circulating levels of thyroid hormones in humans is unclear, however, because the results of available studies are inconsistent. /// The aim of the present study is to examine the possible relationships between concentrations of environmental pollutants and thyroid hormone levels in human umbilical cord blood. /// We measured concentrations of environmental pollutants [including selected PCBs, dioxin-like compounds, hexachlorobenzene, p,p'-DDE (dichlorodiphenyldichloroethylene), cadmium, lead] and thyroid hormones in the cord blood of 198 neonates. /// A statistically significant inverse relationship between concentrations of organochlorine compounds and levels of both free triiodothyronine (fT₃) and free thyroxine (fT₄), but not thyroid-stimulating hormone, was observed. We found no association between concentrations of heavy metals and thyroid hormone levels. /// Our results suggest that environmental chemicals may affect the thyroid system of human neonates. Although the differences in fT₃ and fF₄ levels associated with the organochlorine compounds were within the normal range, the observed interferences may still have detrimental effects on the neurologic development of the individual children, given the importance of thyroid hormones in brain development.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>18087600</pmid><doi>10.1289/ehp.10486</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental health perspectives, 2007-12, Vol.115 (12), p.1780-1786 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Blood Blood plasma Chemical hazards Chidren's Health Chlorinated hydrocarbons Cord blood Environmental health Environmental Pollutants - blood Female Fetal blood Fetal Blood - chemistry Health aspects Humans Hydrocarbons, Chlorinated - blood Infant, Newborn Infants Organochlorine compounds Polychlorinated biphenyls Pregnancy Regression Analysis Thyroid hormones Thyroid Hormones - blood |
| title | Association of Thyroid Hormone Concentrations with Levels of Organochlorine Compounds in Cord Blood of Neonates |
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