The Carboxy-Terminal Tail of Pyruvate Dehydrogenase Kinase 2 Is Required for the Kinase Activity

Pyruvate dehydrogenase kinase 2 (PDK2) is a prototypical mitochondrial protein kinase that regulates the activity of the pyruvate dehydrogenase complex. Recent structural studies have established that PDK2 consists of a catalytic core built of the B and K domains and the relatively long amino and ca...

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Veröffentlicht in:	Biochemistry (Easton) 2005-10, Vol.44 (41), p.13573-13582
Hauptverfasser:	Klyuyeva, Alla, Tuganova, Alina, Popov, Kirill M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Amino Acid Sequence Animals Calorimetry Electrophoresis, Polyacrylamide Gel Molecular Sequence Data Protein Kinases - chemistry Protein Kinases - metabolism Protein Structure, Tertiary Protein-Serine-Threonine Kinases Pyruvate Dehydrogenase Complex - metabolism Rats Sequence Alignment Thermodynamics
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