A hemolysin associated with the mumps virus
1. A factor capable of causing the hemolysis of the erythrocytes of man, chicken, and sheep occurs in the amniotic and allantoic fluids of chick embryos infected with the virus of mumps. 2. The hemolysin has not been found in normal fluids or in those infected with PR8 or Lee B strains of influenza...
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| Veröffentlicht in: | The Journal of experimental medicine 1948-11, Vol.88 (5), p.503-514 |
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| container_title | The Journal of experimental medicine |
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| creator | MORGAN, H R ENDERS, J F WAGLEY, P F |
| description | 1. A factor capable of causing the hemolysis of the erythrocytes of man, chicken, and sheep occurs in the amniotic and allantoic fluids of chick embryos infected with the virus of mumps. 2. The hemolysin has not been found in normal fluids or in those infected with PR8 or Lee B strains of influenza virus. 3. The hemolysin is definitely inhibited by the serum of man and monkey convalescent from mumps, but only slightly by the serum of the acute phase. 4. The hemolysin is almost completely inactivated at 50 degrees C. after 10 minutes. It exhibits maximal activity at 37 degrees C. and is completely inactive at 4 degrees C. A pH range from about 7.0 to 8.0 allows for maximum activity. 5. Adsorption and elution of the hemolysin with red blood cells has been demonstrated. After elution of the hemolysin, the red blood cells exhibit an increased osmotic fragility. Similar treatment of red cells with influenza virus did not alter this property. 6. The relationship of the hemolysin to the hemagglutinin and the enzyme-like behavior of the former have been discussed. |
| doi_str_mv | 10.1084/jem.88.5.503 |
| format | Article |
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A factor capable of causing the hemolysis of the erythrocytes of man, chicken, and sheep occurs in the amniotic and allantoic fluids of chick embryos infected with the virus of mumps. 2. The hemolysin has not been found in normal fluids or in those infected with PR8 or Lee B strains of influenza virus. 3. The hemolysin is definitely inhibited by the serum of man and monkey convalescent from mumps, but only slightly by the serum of the acute phase. 4. The hemolysin is almost completely inactivated at 50 degrees C. after 10 minutes. It exhibits maximal activity at 37 degrees C. and is completely inactive at 4 degrees C. A pH range from about 7.0 to 8.0 allows for maximum activity. 5. Adsorption and elution of the hemolysin with red blood cells has been demonstrated. After elution of the hemolysin, the red blood cells exhibit an increased osmotic fragility. Similar treatment of red cells with influenza virus did not alter this property. 6. The relationship of the hemolysin to the hemagglutinin and the enzyme-like behavior of the former have been discussed.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.88.5.503</identifier><identifier>PMID: 18892425</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; Chick Embryo ; Chickens ; Erythrocytes ; Hemolysin Proteins ; Humans ; Male ; Mumps ; Mumps virus ; Old Medline ; Orthomyxoviridae ; Sheep</subject><ispartof>The Journal of experimental medicine, 1948-11, Vol.88 (5), p.503-514</ispartof><rights>Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-3b35774bc5659a708768b93958ad884506bd9447e27aa1ecbd809aec64660ba93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18892425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORGAN, H R</creatorcontrib><creatorcontrib>ENDERS, J F</creatorcontrib><creatorcontrib>WAGLEY, P F</creatorcontrib><title>A hemolysin associated with the mumps virus</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>1. A factor capable of causing the hemolysis of the erythrocytes of man, chicken, and sheep occurs in the amniotic and allantoic fluids of chick embryos infected with the virus of mumps. 2. The hemolysin has not been found in normal fluids or in those infected with PR8 or Lee B strains of influenza virus. 3. The hemolysin is definitely inhibited by the serum of man and monkey convalescent from mumps, but only slightly by the serum of the acute phase. 4. The hemolysin is almost completely inactivated at 50 degrees C. after 10 minutes. It exhibits maximal activity at 37 degrees C. and is completely inactive at 4 degrees C. A pH range from about 7.0 to 8.0 allows for maximum activity. 5. Adsorption and elution of the hemolysin with red blood cells has been demonstrated. After elution of the hemolysin, the red blood cells exhibit an increased osmotic fragility. Similar treatment of red cells with influenza virus did not alter this property. 6. The relationship of the hemolysin to the hemagglutinin and the enzyme-like behavior of the former have been discussed.</description><subject>Animals</subject><subject>Chick Embryo</subject><subject>Chickens</subject><subject>Erythrocytes</subject><subject>Hemolysin Proteins</subject><subject>Humans</subject><subject>Male</subject><subject>Mumps</subject><subject>Mumps virus</subject><subject>Old Medline</subject><subject>Orthomyxoviridae</subject><subject>Sheep</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1948</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLw0AQgBdRtFZvniUnL5o4-8rOXoRSfEHBi56XTbI1W_Ko2aTSf2-kxcdpDvPxzfARckEhoYDiduXqBDGRiQR-QCZUCoi15HhIJgCMxRRAnZDTEFYAVAiZHpMTiqiZYHJCrmdR6eq22gbfRDaENve2d0X06fsy6ksX1UO9DtHGd0M4I0dLWwV3vp9T8vZw_zp_ihcvj8_z2SLOObI-5hmXSoksl6nUVgGqFDPNtURbIAoJaVZoIZRjylrq8qxA0NblqUhTyKzmU3K3866HrHZF7pq-s5VZd7623da01pv_m8aX5r3dGEa5RMFGwdVe0LUfgwu9qX3IXVXZxrVDMEpIxkHwEbzZgXnXhtC55c8RCua7rhnrGkQjzVh3xC__PvYL73PyLyPYda8</recordid><startdate>19481101</startdate><enddate>19481101</enddate><creator>MORGAN, H R</creator><creator>ENDERS, J F</creator><creator>WAGLEY, P F</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19481101</creationdate><title>A hemolysin associated with the mumps virus</title><author>MORGAN, H R ; ENDERS, J F ; WAGLEY, P F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-3b35774bc5659a708768b93958ad884506bd9447e27aa1ecbd809aec64660ba93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1948</creationdate><topic>Animals</topic><topic>Chick Embryo</topic><topic>Chickens</topic><topic>Erythrocytes</topic><topic>Hemolysin Proteins</topic><topic>Humans</topic><topic>Male</topic><topic>Mumps</topic><topic>Mumps virus</topic><topic>Old Medline</topic><topic>Orthomyxoviridae</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORGAN, H R</creatorcontrib><creatorcontrib>ENDERS, J F</creatorcontrib><creatorcontrib>WAGLEY, P F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORGAN, H R</au><au>ENDERS, J F</au><au>WAGLEY, P F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A hemolysin associated with the mumps virus</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1948-11-01</date><risdate>1948</risdate><volume>88</volume><issue>5</issue><spage>503</spage><epage>514</epage><pages>503-514</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>1. A factor capable of causing the hemolysis of the erythrocytes of man, chicken, and sheep occurs in the amniotic and allantoic fluids of chick embryos infected with the virus of mumps. 2. The hemolysin has not been found in normal fluids or in those infected with PR8 or Lee B strains of influenza virus. 3. The hemolysin is definitely inhibited by the serum of man and monkey convalescent from mumps, but only slightly by the serum of the acute phase. 4. The hemolysin is almost completely inactivated at 50 degrees C. after 10 minutes. It exhibits maximal activity at 37 degrees C. and is completely inactive at 4 degrees C. A pH range from about 7.0 to 8.0 allows for maximum activity. 5. Adsorption and elution of the hemolysin with red blood cells has been demonstrated. After elution of the hemolysin, the red blood cells exhibit an increased osmotic fragility. Similar treatment of red cells with influenza virus did not alter this property. 6. The relationship of the hemolysin to the hemagglutinin and the enzyme-like behavior of the former have been discussed.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>18892425</pmid><doi>10.1084/jem.88.5.503</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Chick Embryo Chickens Erythrocytes Hemolysin Proteins Humans Male Mumps Mumps virus Old Medline Orthomyxoviridae Sheep |
| title | A hemolysin associated with the mumps virus |
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