Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitoneal and intranasal routes of infection

Infection of guinea-pigs by intranasal (i.n.) instillation of 109 viable organisms of two newly isolated strains of Legionella pneumophila (74/81, serogroup 1; 166/81, serogroup 3) did not induce disease, but 104 organisms administered as a small particle aerosol (< 5 μm diameter) produced a fata...

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Veröffentlicht in:	The Journal of hygiene 1983-02, Vol.90 (1), p.81-89
Hauptverfasser:	Fitzgeorge, R. B., Baskerville, A., Broster, M., Hambleton, P., Dennis, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Animals Antibodies Antibodies, Bacterial - analysis Antibody formation Callitrichinae Disease Models, Animal Dosage Epidemiology Female Guinea Pigs Infections Legionella - immunology Legionella - pathogenicity Legionella - physiology Legionella pneumophila Legionnaires disease Legionnaires' Disease - microbiology Legionnaires' Disease - pathology Lung - microbiology Lung - pathology Lungs Macaca fascicularis Macaca mulatta Male Mice Nose Peritoneum
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