Chromosomal Influence on Meiotic Spindle Assembly: Abnormal Meiosis I in Female Mlh1 Mutant Mice

In mouse oocytes, the first meiotic spindle is formed through the action of multiple microtubule organizing centers rather than a pair of centrosomes. Although the chromosomes are thought to play a major role in organizing the meiotic spindle, it remains unclear how a stable bipolar spindle is estab...

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Veröffentlicht in:	The Journal of cell biology 1999-06, Vol.145 (7), p.1395-1406
Hauptverfasser:	Woods, Linda M., Hodges, Craig A., Baart, Esther, Baker, Sean M., Liskay, Michael, Hunt, Patricia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Anaphase Anaphase - genetics Anaphase - physiology Animals Carrier Proteins Cell cycle Cell division Cellular biology Centrosome - metabolism Chromosome Segregation - genetics Chromosome Segregation - physiology Chromosomes Chromosomes - genetics Chromosomes - physiology Deoxyribonucleic acid DNA Female Genes Homozygote Kinetochores Kinetochores - physiology Male Meiosis Meiosis - genetics Meiosis - physiology Metaphase Mice Mice, Knockout Microtubules Mitotic spindle apparatus Mutation MutL Protein Homolog 1 Neoplasm Proteins - genetics Neoplasm Proteins - physiology Nuclear Proteins Oocytes Oocytes - physiology Recombination, Genetic - genetics Recombination, Genetic - physiology Regular Rodents Saccharomyces cerevisiae Sex chromosomes Sex Chromosomes - genetics Sex Chromosomes - physiology Spindle Apparatus - physiology
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