CENP-E Function at Kinetochores Is Essential for Chromosome Alignment

CENP-E is a kinesin-like protein that binds to kinetochores and may provide functions that are critical for normal chromosome motility during mitosis. To directly test the in vivo function of CENP-E, we microinjected affinity-purified antibodies to block the assembly of CENP-E onto kinetochores and...

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Veröffentlicht in:	The Journal of cell biology 1997-12, Vol.139 (6), p.1373-1382
Hauptverfasser:	Schaar, B. T., Chan, G. K. T., Maddox, P., Salmon, E. D., Yen, T. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Animals Antibodies Antibodies - pharmacology Cell Line Cells Centromeres Chromosomal Proteins, Non-Histone - biosynthesis Chromosomal Proteins, Non-Histone - physiology Chromosomes Chromosomes - physiology Chromosomes - ultrastructure Genes Green Fluorescent Proteins HeLa Cells Humans Kinetics Kinetochores Kinetochores - physiology Kinetochores - ultrastructure Luminescent Proteins - biosynthesis Microtubules Mitosis Mitotic spindle apparatus Models, Biological Molecular biology Mutagenesis Proteins Rabbits Recombinant Fusion Proteins - biosynthesis Sequence Deletion Transfection
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