A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

Exoribonucleases are important enzymes for the turnover of cellular RNA species. We have isolated the first mammalian cDNA from mouse demonstrated to encode a 5′-3′ exoribonuclease. The structural conservation of the predicted protein and complementation data in Saccharomyces cerevisiae suggest a ro...

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Veröffentlicht in:	The Journal of cell biology 1997-02, Vol.136 (4), p.761-773
Hauptverfasser:	Bashkirov, Vladimir I., Scherthan, Harry, Solinger, Jachen A., Buerstedde, Jean-Marie, Heyer, Wolf-Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Cell lines Cells Cellular biology Complementary DNA Cytoplasm - enzymology Cytoplasm - metabolism Deoxyribonucleases - genetics Deoxyribonucleic acid DNA DNA, Complementary - chemistry DNA, Complementary - isolation & purification DNA, Complementary - physiology Enzymes Exoribonucleases - genetics Exoribonucleases - metabolism Fungal Proteins - genetics Guanine - metabolism Messenger RNA Mice Mice, Inbred BALB C Molecular Sequence Data Plasmids Ribonucleic acid RNA RNA - metabolism Rodents Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Substrate Specificity Yeasts
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