Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy
Live type 4 adenovirus contained in enteric-coated tablets was given to 2628 military recruits. In two trials, the enteric adenovirus vaccine reduced febrile and afebrile adenovirus illness by about 90% or more. Moreover, a decided protective effect against subclinical adenovirus infection as eviden...
Gespeichert in:
| Veröffentlicht in: | Epidemiology and infection 1968-12, Vol.66 (4), p.499-511 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 511 |
|---|---|
| container_issue | 4 |
| container_start_page | 499 |
| container_title | Epidemiology and infection |
| container_volume | 66 |
| creator | Van Der Veen, J. Abarbanel, M. F. W. Oei, Kiem Giok |
| description | Live type 4 adenovirus contained in enteric-coated tablets was given to 2628 military recruits. In two trials, the enteric adenovirus vaccine reduced febrile and afebrile adenovirus illness by about 90% or more. Moreover, a decided protective effect against subclinical adenovirus infection as evidenced by seroconversion was found. The antibody-stimulating effect of enteric adenovirus vaccine was not an adequate measure of its protective capacity. The neutralizing antibody response of recruits given vaccine was poor in comparison with the antibody response to naturally acquired infection with type 4 adenovirus. The latter response was related to the severity of infection. We are indebted to Colonel Dr B. J. W. Beunders, Head of the Division of Preventive Medicine of the Royal Netherlands Army, for granting us facilities to conduct this study and to Misses W. T. C. J. Smulders, E. M. J. C. Vallas, J. E. M. Dusseldorp and M. M. J. P. Keeris for their valuable technical assistance. |
| doi_str_mv | 10.1017/S0022172400028242 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2130674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0022172400028242</cupid><jstor_id>3861307</jstor_id><sourcerecordid>3861307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-ef429bd648172501da38af27fdbfd7ce44529fe16c762bd72b5831951836a5fc3</originalsourceid><addsrcrecordid>eNp9kV-LEzEUxQdR1rr6AQSFefJtNP8myfggaHF3hYLIqg--xExys5s6nYxJpmu_vSktRRF8Ssjv5NxzOVX1FKOXGGHx6hohQrAgDJWLJIzcqxaY8a5hDHX3qwXqWtQQLuXD6lFK66LqiBRn1RmjiHYtXlTfv2pj_KizD2N95_NtPfgt1Hk3Qc1qbWEMWx_n9LqGrR7mgy64Wo_Z98Hu6ghpCmOC8mLrKYYMJu8dwDlvtNk9rh44PSR4cjzPqy8X7z8vr5rVx8sPy7erxrBO5AYcI11vOZNlnRZhq6nUjghne2eFAcZa0jnA3AhOeitI30qKywqSct06Q8-rNwffae43YA2MOepBTdFvdNypoL36m4z-Vt2ErSKYIi5YMXhxNIjh5wwpq41PBoZBjxDmpGSLBBJEFCE-CE0MKUVwpyEYqX0t6p9ayp_nf6Y7_Tj2UPizA1-nHOIJU8lLuv3I5oB9yvDrhHX8obigolX88pOiq2_tFX53rZZFT48R9aaP3t6AWoc5jqWA_4T8Dc7OscU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>85070727</pqid></control><display><type>article</type><title>Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><source>PubMed Central</source><creator>Van Der Veen, J. ; Abarbanel, M. F. W. ; Oei, Kiem Giok</creator><creatorcontrib>Van Der Veen, J. ; Abarbanel, M. F. W. ; Oei, Kiem Giok</creatorcontrib><description>Live type 4 adenovirus contained in enteric-coated tablets was given to 2628 military recruits. In two trials, the enteric adenovirus vaccine reduced febrile and afebrile adenovirus illness by about 90% or more. Moreover, a decided protective effect against subclinical adenovirus infection as evidenced by seroconversion was found. The antibody-stimulating effect of enteric adenovirus vaccine was not an adequate measure of its protective capacity. The neutralizing antibody response of recruits given vaccine was poor in comparison with the antibody response to naturally acquired infection with type 4 adenovirus. The latter response was related to the severity of infection. We are indebted to Colonel Dr B. J. W. Beunders, Head of the Division of Preventive Medicine of the Royal Netherlands Army, for granting us facilities to conduct this study and to Misses W. T. C. J. Smulders, E. M. J. C. Vallas, J. E. M. Dusseldorp and M. M. J. P. Keeris for their valuable technical assistance.</description><identifier>ISSN: 0950-2688</identifier><identifier>ISSN: 0022-1724</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0022172400028242</identifier><identifier>PMID: 4303951</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adenoviridae infections ; Adenoviridae Infections - prevention & control ; Adenoviruses ; Antibodies ; Antibody Formation ; Diseases ; Fever - epidemiology ; Humans ; Infections ; Male ; Military Personnel ; Military recruitment ; Neutralization Tests ; Neutralizing antibodies ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - prevention & control ; Tablets, Enteric-Coated ; Vaccination ; Viral Vaccines ; Viruses</subject><ispartof>Epidemiology and infection, 1968-12, Vol.66 (4), p.499-511</ispartof><rights>Copyright © Cambridge University Press 1968</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-ef429bd648172501da38af27fdbfd7ce44529fe16c762bd72b5831951836a5fc3</citedby><cites>FETCH-LOGICAL-c497t-ef429bd648172501da38af27fdbfd7ce44529fe16c762bd72b5831951836a5fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3861307$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3861307$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53770,53772,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4303951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Der Veen, J.</creatorcontrib><creatorcontrib>Abarbanel, M. F. W.</creatorcontrib><creatorcontrib>Oei, Kiem Giok</creatorcontrib><title>Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Live type 4 adenovirus contained in enteric-coated tablets was given to 2628 military recruits. In two trials, the enteric adenovirus vaccine reduced febrile and afebrile adenovirus illness by about 90% or more. Moreover, a decided protective effect against subclinical adenovirus infection as evidenced by seroconversion was found. The antibody-stimulating effect of enteric adenovirus vaccine was not an adequate measure of its protective capacity. The neutralizing antibody response of recruits given vaccine was poor in comparison with the antibody response to naturally acquired infection with type 4 adenovirus. The latter response was related to the severity of infection. We are indebted to Colonel Dr B. J. W. Beunders, Head of the Division of Preventive Medicine of the Royal Netherlands Army, for granting us facilities to conduct this study and to Misses W. T. C. J. Smulders, E. M. J. C. Vallas, J. E. M. Dusseldorp and M. M. J. P. Keeris for their valuable technical assistance.</description><subject>Adenoviridae infections</subject><subject>Adenoviridae Infections - prevention & control</subject><subject>Adenoviruses</subject><subject>Antibodies</subject><subject>Antibody Formation</subject><subject>Diseases</subject><subject>Fever - epidemiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Military Personnel</subject><subject>Military recruitment</subject><subject>Neutralization Tests</subject><subject>Neutralizing antibodies</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Tablets, Enteric-Coated</subject><subject>Vaccination</subject><subject>Viral Vaccines</subject><subject>Viruses</subject><issn>0950-2688</issn><issn>0022-1724</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-LEzEUxQdR1rr6AQSFefJtNP8myfggaHF3hYLIqg--xExys5s6nYxJpmu_vSktRRF8Ssjv5NxzOVX1FKOXGGHx6hohQrAgDJWLJIzcqxaY8a5hDHX3qwXqWtQQLuXD6lFK66LqiBRn1RmjiHYtXlTfv2pj_KizD2N95_NtPfgt1Hk3Qc1qbWEMWx_n9LqGrR7mgy64Wo_Z98Hu6ghpCmOC8mLrKYYMJu8dwDlvtNk9rh44PSR4cjzPqy8X7z8vr5rVx8sPy7erxrBO5AYcI11vOZNlnRZhq6nUjghne2eFAcZa0jnA3AhOeitI30qKywqSct06Q8-rNwffae43YA2MOepBTdFvdNypoL36m4z-Vt2ErSKYIi5YMXhxNIjh5wwpq41PBoZBjxDmpGSLBBJEFCE-CE0MKUVwpyEYqX0t6p9ayp_nf6Y7_Tj2UPizA1-nHOIJU8lLuv3I5oB9yvDrhHX8obigolX88pOiq2_tFX53rZZFT48R9aaP3t6AWoc5jqWA_4T8Dc7OscU</recordid><startdate>19681201</startdate><enddate>19681201</enddate><creator>Van Der Veen, J.</creator><creator>Abarbanel, M. F. W.</creator><creator>Oei, Kiem Giok</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19681201</creationdate><title>Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy</title><author>Van Der Veen, J. ; Abarbanel, M. F. W. ; Oei, Kiem Giok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-ef429bd648172501da38af27fdbfd7ce44529fe16c762bd72b5831951836a5fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Adenoviridae infections</topic><topic>Adenoviridae Infections - prevention & control</topic><topic>Adenoviruses</topic><topic>Antibodies</topic><topic>Antibody Formation</topic><topic>Diseases</topic><topic>Fever - epidemiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Military Personnel</topic><topic>Military recruitment</topic><topic>Neutralization Tests</topic><topic>Neutralizing antibodies</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Tablets, Enteric-Coated</topic><topic>Vaccination</topic><topic>Viral Vaccines</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Der Veen, J.</creatorcontrib><creatorcontrib>Abarbanel, M. F. W.</creatorcontrib><creatorcontrib>Oei, Kiem Giok</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Der Veen, J.</au><au>Abarbanel, M. F. W.</au><au>Oei, Kiem Giok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>1968-12-01</date><risdate>1968</risdate><volume>66</volume><issue>4</issue><spage>499</spage><epage>511</epage><pages>499-511</pages><issn>0950-2688</issn><issn>0022-1724</issn><eissn>1469-4409</eissn><abstract>Live type 4 adenovirus contained in enteric-coated tablets was given to 2628 military recruits. In two trials, the enteric adenovirus vaccine reduced febrile and afebrile adenovirus illness by about 90% or more. Moreover, a decided protective effect against subclinical adenovirus infection as evidenced by seroconversion was found. The antibody-stimulating effect of enteric adenovirus vaccine was not an adequate measure of its protective capacity. The neutralizing antibody response of recruits given vaccine was poor in comparison with the antibody response to naturally acquired infection with type 4 adenovirus. The latter response was related to the severity of infection. We are indebted to Colonel Dr B. J. W. Beunders, Head of the Division of Preventive Medicine of the Royal Netherlands Army, for granting us facilities to conduct this study and to Misses W. T. C. J. Smulders, E. M. J. C. Vallas, J. E. M. Dusseldorp and M. M. J. P. Keeris for their valuable technical assistance.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>4303951</pmid><doi>10.1017/S0022172400028242</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-2688 |
| ispartof | Epidemiology and infection, 1968-12, Vol.66 (4), p.499-511 |
| issn | 0950-2688 0022-1724 1469-4409 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2130674 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Adenoviridae infections Adenoviridae Infections - prevention & control Adenoviruses Antibodies Antibody Formation Diseases Fever - epidemiology Humans Infections Male Military Personnel Military recruitment Neutralization Tests Neutralizing antibodies Respiratory Tract Infections - epidemiology Respiratory Tract Infections - prevention & control Tablets, Enteric-Coated Vaccination Viral Vaccines Viruses |
| title | Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T03%3A52%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vaccination%20with%20live%20type%204%20adenovirus:%20evaluation%20of%20antibody%20response%20and%20protective%20efficacy&rft.jtitle=Epidemiology%20and%20infection&rft.au=Van%20Der%20Veen,%20J.&rft.date=1968-12-01&rft.volume=66&rft.issue=4&rft.spage=499&rft.epage=511&rft.pages=499-511&rft.issn=0950-2688&rft.eissn=1469-4409&rft_id=info:doi/10.1017/S0022172400028242&rft_dat=%3Cjstor_pubme%3E3861307%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=85070727&rft_id=info:pmid/4303951&rft_cupid=10_1017_S0022172400028242&rft_jstor_id=3861307&rfr_iscdi=true |