Hepatocyte growth factor induces epithelial cell motility through transactivation of the epidermal growth factor receptor

Hepatocyte growth factor (HGF) is a potent inducer of motility in epithelial cells. Since we have previously found that activation of the epidermal growth factor receptor (EGFR) is an absolute prerequisite for induction of motility of corneal epithelial cells after wounding, we investigated whether...

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Veröffentlicht in:	Experimental cell research 2007-09, Vol.313 (15), p.3319-3325
Hauptverfasser:	Spix, Julie K., Chay, Edward Y., Block, Ethan R., Klarlund, Jes K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cell motility Cell Movement Cells, Cultured Cellular biology Cornea Cornea - cytology Cornea - metabolism Dogs Enzyme Activation Epidermal growth factor Epithelial Cells - physiology Extracellular Signal-Regulated MAP Kinases - metabolism Hepatocyte growth factor Hepatocyte Growth Factor - biosynthesis Hepatocyte Growth Factor - pharmacology Hepatocyte Growth Factor - physiology Humans Ophthalmology Phosphorylation Receptor, Epidermal Growth Factor - metabolism Signal Transduction Transactivation Transcriptional Activation Wound healing
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