Rad54 Oligomers Translocate and Cross-bridge Double-stranded DNA to Stimulate Synapsis

Rad54 is a key component of the eukaryotic recombination machinery. Its presence in DNA strand-exchange reactions in vitro results in a significant stimulation of the overall reaction rate. Using untagged Rad54, we show that this stimulation can be attributed to enhancement of the formation of a key...

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Veröffentlicht in:	Journal of molecular biology 2007-11, Vol.374 (3), p.618-640
Hauptverfasser:	Bianco, Piero R., Bradfield, Justin J., Castanza, Lauren R., Donnelly, Andrea N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Biopolymers - chemistry Biopolymers - metabolism Chromatin Chromosome Pairing DNA - metabolism DNA helicase DNA Helicases Glutathione Transferase - metabolism Humans Hydrolysis Microscopy, Fluorescence Nuclear Proteins - chemistry Nuclear Proteins - metabolism Protein Transport Rad54 Recombination Single molecule
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