A CONTRIBUTION TO THE STUDY OF PANCREAS INTOXICATION
1. A toxic constituent is present in the fresh pancreas of dogs before trypsinogen can have been activated. 2. The toxic fraction is present in the beta-nucleoprotein, and therefore is thermostable. 3. It is gradually destroyed by autolysis but can be obtained in concentrated form from a gland which...
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| Veröffentlicht in: | The Journal of experimental medicine 1917-02, Vol.25 (2), p.277-283 |
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| container_title | The Journal of experimental medicine |
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| creator | Goodpasture, E W |
| description | 1. A toxic constituent is present in the fresh pancreas of dogs before trypsinogen can have been activated. 2. The toxic fraction is present in the beta-nucleoprotein, and therefore is thermostable. 3. It is gradually destroyed by autolysis but can be obtained in concentrated form from a gland which has autolyzed 24 hours. 4. The toxic material is probably protein in nature. 5. Intravenous or intraperitoneal injection of from 0.05 to O.I gm. per kilo of body weight is usually fatal and elicits in dogs symptoms comparable to those of spontaneous hemorrhagic necrosis of the pancreas. 6. Dog pancreas differs from that of beef or pig in that guanylic acid and toxic protein combined with it are slowly broken down by autolysis. 7. After autolysis of dog pancreas the toxic protein and guanylic acid may be separated and obtained in relatively pure form. |
| doi_str_mv | 10.1084/jem.25.2.277 |
| format | Article |
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A toxic constituent is present in the fresh pancreas of dogs before trypsinogen can have been activated. 2. The toxic fraction is present in the beta-nucleoprotein, and therefore is thermostable. 3. It is gradually destroyed by autolysis but can be obtained in concentrated form from a gland which has autolyzed 24 hours. 4. The toxic material is probably protein in nature. 5. Intravenous or intraperitoneal injection of from 0.05 to O.I gm. per kilo of body weight is usually fatal and elicits in dogs symptoms comparable to those of spontaneous hemorrhagic necrosis of the pancreas. 6. Dog pancreas differs from that of beef or pig in that guanylic acid and toxic protein combined with it are slowly broken down by autolysis. 7. 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A toxic constituent is present in the fresh pancreas of dogs before trypsinogen can have been activated. 2. The toxic fraction is present in the beta-nucleoprotein, and therefore is thermostable. 3. It is gradually destroyed by autolysis but can be obtained in concentrated form from a gland which has autolyzed 24 hours. 4. The toxic material is probably protein in nature. 5. Intravenous or intraperitoneal injection of from 0.05 to O.I gm. per kilo of body weight is usually fatal and elicits in dogs symptoms comparable to those of spontaneous hemorrhagic necrosis of the pancreas. 6. Dog pancreas differs from that of beef or pig in that guanylic acid and toxic protein combined with it are slowly broken down by autolysis. 7. 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A toxic constituent is present in the fresh pancreas of dogs before trypsinogen can have been activated. 2. The toxic fraction is present in the beta-nucleoprotein, and therefore is thermostable. 3. It is gradually destroyed by autolysis but can be obtained in concentrated form from a gland which has autolyzed 24 hours. 4. The toxic material is probably protein in nature. 5. Intravenous or intraperitoneal injection of from 0.05 to O.I gm. per kilo of body weight is usually fatal and elicits in dogs symptoms comparable to those of spontaneous hemorrhagic necrosis of the pancreas. 6. Dog pancreas differs from that of beef or pig in that guanylic acid and toxic protein combined with it are slowly broken down by autolysis. 7. After autolysis of dog pancreas the toxic protein and guanylic acid may be separated and obtained in relatively pure form.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>19868087</pmid><doi>10.1084/jem.25.2.277</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | A CONTRIBUTION TO THE STUDY OF PANCREAS INTOXICATION |
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