Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma

Emerging evidence suggests that both human stem cells and mature stromal cells can play an important role in the development and growth of human malignancies. In contrast to these tumor-promoting properties, we observed that in an in vivo model of Kaposi's sarcoma (KS), intravenously (i.v.) inj...

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Veröffentlicht in:	The Journal of experimental medicine 2006-05, Vol.203 (5), p.1235-1247
Hauptverfasser:	Khakoo, Aarif Y, Pati, Shibani, Anderson, Stasia A, Reid, William, Elshal, Mohamed F, Rovira, Ilsa I, Nguyen, Ahn T, Malide, Daniela, Combs, Christian A, Hall, Gentzon, Zhang, Jianhu, Raffeld, Mark, Rogers, Terry B, Stetler-Stevenson, William, Frank, Joseph A, Reitz, Marvin, Finkel, Toren
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Enzyme Activation - immunology Graft vs Tumor Effect - immunology Male Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - immunology Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Oncogene Protein v-akt - immunology Sarcoma, Kaposi - immunology Sarcoma, Kaposi - pathology Sarcoma, Kaposi - therapy Stromal Cells - immunology Stromal Cells - transplantation Transplantation, Heterologous Tumor Cells, Cultured
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