Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

The tyrosine kinase called pp125FAK is believed to play an important role in integrin-mediated signal transduction. pp125FAK is associated both functionally and spatially with integrins, which are the cell surface receptors for extracellular matrix components. Although the precise function of pp125F...

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Veröffentlicht in:	The Journal of cell biology 1996-12, Vol.135 (5), p.1383-1390
Hauptverfasser:	Hungerford, J E, Compton, M T, Matter, M L, Hoffstrom, B G, Otey, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis Binding Sites Binding, Competitive Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Cell Adhesion Molecules - pharmacology Cell Membrane - ultrastructure Cell Nucleus - ultrastructure Cells, Cultured Cellular biology Chick Embryo Enzyme Activation Fibroblasts Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Integrin beta1 - chemistry Integrin beta1 - metabolism Molecular Sequence Data Peptides - chemistry Peptides - metabolism Protein-Tyrosine Kinases - immunology Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - pharmacology Proteins Signal Transduction
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