Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction

wingless, the Drosophila homologue of the proto-oncogene Wnt-1, encodes a secreted glycoprotein that regulates differentiation and proliferation of nearby cells. Here we report on the biochemical mechanism(s) by which the wingless signal is transmitted from cell to cell. When expressed in S2 cells,...

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Veröffentlicht in:	The Journal of cell biology 1996-11, Vol.135 (3), p.819-827
Hauptverfasser:	Reichsman, F. (University of Massachusetts, Amherst, MA.), Smith, L, Cumberledge, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cell adhesion Cell Line Cell lines Cell Membrane - chemistry Cells Cellular biology CELLULE CELULAS CULTIVO DE CELULAS CULTURE DE CELLULE Drosophila Drosophila - physiology DROSOPHILA MELANOGASTER Drosophila Proteins Enzyme Inhibitors - pharmacology Epithelial cells Extracellular Matrix - chemistry FOSFORILACION GLICOPROTEINAS GLICOSAMINOGLICANOS GLYCOPROTEINE GLYCOSAMINOGLYCANE Glycosaminoglycans Glycosaminoglycans - metabolism Glycosaminoglycans - pharmacology Heparin HEPARINA HEPARINE IMMUNOLOGIE INMUNOLOGIA Insects Perchlorates - pharmacology PHOSPHORYLATION Polysaccharide-Lyases Protein Binding Protein Processing, Post-Translational PROTEINA QUINASA PROTEINAS PROTEINAS AGLUTINANTES PROTEINE PROTEINE DE LIAISON PROTEINE KINASE Proteins Proteoglycans Proteoglycans - metabolism Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - pharmacology Receptors SECRECION SECRETION Signal Transduction - physiology Sodium Compounds - pharmacology Sulfate Adenylyltransferase - antagonists & inhibitors Sulfates Wnt1 Protein
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