A Hyaluronidase Activity of the Sperm Plasma Membrane Protein PH-20 Enables Sperm to Penetrate the Cumulus Cell Layer Surrounding the Egg

A typical mammalian egg is surrounded by an outer layer of about 3,000 cumulus cells embedded in an extracellular matrix rich in hyaluronic acid. A current, widely proposed model is that the fertilizing sperm, while it is acrosome intact, passes through the cumulus cell layer and binds to the egg zo...

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Veröffentlicht in:	The Journal of cell biology 1994-06, Vol.125 (5), p.1157-1163
Hauptverfasser:	Lin, Ying, Mahan, Kimberly, Lathrop, William F., Myles, Diana G., Primakoff, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome reaction Acrosomes Animal reproduction Animals Antibodies Base Sequence Biological and medical sciences Cell Adhesion Molecules - metabolism Cell Membrane - enzymology Cell membranes Cells Cellular biology DNA Primers - chemistry Female Fertilization Fundamental and applied biological sciences. Psychology Herpes zoster Humans Hyaluronoglucosaminidase - metabolism Insemination Macaca mulatta Male Mammalian male genital system Membranes Mice Molecular Sequence Data Morphology. Physiology Ova Proteins Sperm-Ovum Interactions Spermatozoa Spermatozoa - enzymology Type C Phospholipases - metabolism Vertebrates: reproduction
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