Cytokine-Mediated Protein Kinase C Activation Is a Signal for Lineage Determination in Bipotential Granulocyte Macrophage Colony-Forming Cells

Granulocyte macrophage colony-forming cells (GM-CFC) have the potential to develop into either macrophages and/or neutrophils. With a highly enriched population of these cells we have found that although GM-CFC are equally responsive to macrophage colony stimulating factor (M-CSF) and stem cell fact...

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Veröffentlicht in:	The Journal of cell biology 1994-05, Vol.125 (3), p.651-659
Hauptverfasser:	Whetton, Anthony D., Heyworth, Clare M., Nicholls, Sian E., Evans, Caroline A., Lord, Janet M., Dexter, T. Michael, Owen-Lynch, P. Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow Cells Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Division Cell growth Cell physiology Cell Separation Cells Cells, Cultured Cellular biology Colony stimulating factors Cytokines Diglycerides - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Granulocytes Hematopoiesis Hematopoietic Cell Growth Factors - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - enzymology Hydrolysis In Vitro Techniques Inositol Phosphates - metabolism Leukocytes Macrophage Colony-Stimulating Factor - pharmacology Macrophages Macrophages - cytology Macrophages - enzymology Mice Molecular and cellular biology Neutrophils Neutrophils - cytology Neutrophils - enzymology Protein isoforms Protein Kinase C - metabolism Proteins Receptors Second Messenger Systems Stem Cell Factor
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