Contractile Activity and Cell-Cell Contact Regulate Myofibrillar Organization in Cultured Cardiac Myocytes

Adult feline ventricular myocytes cultured on a laminin-coated substratum reestablish intercellular junctions, yet disassemble their myofibrils. Immunofluorescence microscopy reveals that these nonbeating heart cells lack vinculin-positive focal adhesions; moreover, intercellular junctions are also...

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Veröffentlicht in:	The Journal of cell biology 1993-10, Vol.123 (2), p.323-336
Hauptverfasser:	Simpson, David G., Decker, Marlene L., Clark, William A., Decker, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - analysis Actins - metabolism Agonists Animals Biological and medical sciences Cats Cell Communication - physiology Cells Cells, Cultured Cellular biology Cultured cells Cyclic AMP - metabolism Cyclic AMP - physiology Cytoskeletal proteins Cytoskeletal Proteins - analysis Cytoskeletal Proteins - metabolism Cytoskeletal Proteins - ultrastructure Focal adhesions Fundamental and applied biological sciences. Psychology Gene expression regulation Heart Intercellular Junctions - physiology Intercellular Junctions - ultrastructure Isoproterenol - pharmacology Microscopy, Electron Microscopy, Fluorescence Myocardial Contraction - physiology Myocardium - chemistry Myocardium - cytology Myocardium - ultrastructure Myofibrils Myofibrils - metabolism Myofibrils - physiology Myofibrils - ultrastructure Protein synthesis Proteins Space life sciences Vertebrates: cardiovascular system Vinculin - analysis Vinculin - metabolism
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