Mutations in Human Dynamin Block an Intermediate Stage in Coated Vesicle Formation

The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to block endocytosis at a stage after the initiati...

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Veröffentlicht in:	The Journal of cell biology 1993-08, Vol.122 (3), p.553-563
Hauptverfasser:	van der Bliek, Alexander M., Redelmeier, Thomas E., Damke, Hanna, Tisdale, Ellen J., Meyerowitz, Elliot M., Schmid, Sandra L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Antibodies Biological and medical sciences Ca(2+) Mg(2+)-ATPase - chemistry Ca(2+) Mg(2+)-ATPase - genetics Ca(2+) Mg(2+)-ATPase - physiology Cell physiology Cells Cellular biology Coated vesicles Complementary DNA Drosophila Dynamins Endocytosis Endoplasmic Reticulum - metabolism Endosomes - metabolism Endosomes - ultrastructure Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Genetic mutation Golgi Apparatus - metabolism HeLa Cells Humans Molecular and cellular biology Molecular Sequence Data Mutation Proteins RNA Transfection Transferrin - metabolism
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