Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection

The genesis of human follicular lymphoma (FL) is a multistep process. The initial event is thought to be the chromosomal translocation t(14;18)(q32;q21) juxtaposing the bcl-2 proto-oncogene with the immunoglobulin (Ig) H chain locus joining segment (JH) as an error of D-J or V-D joining in the pre-B...

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Veröffentlicht in:	The Journal of experimental medicine 1992-10, Vol.176 (4), p.1137-1148
Hauptverfasser:	ZELENETZ, A. D, CHEN, T. T, LEVY, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Blotting, Southern Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Cloning, Molecular DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Gene Rearrangement General aspects (metabolism, cell proliferation, established cell line...) Genomic Library Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Lymphoma, Follicular - genetics Lymphoma, Follicular - immunology Lymphoma, Follicular - pathology Medical sciences Molecular Sequence Data Mutation Oligodeoxyribonucleotides Polymerase Chain Reaction - methods Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 Restriction Mapping Translocation, Genetic Tumor cell Tumor Cells, Cultured Tumors
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