Peptide-induced stabilization and intracellular localization of empty HLA class I complexes

The human cell line T2 has been reported to be class I assembly deficient, and accordingly expresses reduced amounts of HLA-A2 and no HLA-B5 at the cell surface. By immunoblotting we observe the steady-state class I heavy chain levels of T2 to be near normal when compared with the identical class I...

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Veröffentlicht in:	The Journal of experimental medicine 1992-07, Vol.176 (1), p.147-156
Hauptverfasser:	BAAS, E. J, VAN SANTEN, H.-M, KLEIJMEER, M. J, GEUZE, H. J, PETERS, P. J, PLOEGH, H. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens beta 2-Microglobulin - analysis Biological and medical sciences Cell Line Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility antigens (hla, h-2 and other systems) Histocompatibility Antigens Class I - analysis HLA-A2 Antigen - analysis HLA-B Antigens - analysis Humans Microscopy, Immunoelectron Molecular immunology Temperature
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