Antitopoisomerase I monoclonal autoantibodies from scleroderma patients and tight skin mouse interact with similar epitopes

We have generated for the first time monoclonal antibodies (mAbs) specific for topoisomerase I (topo I) from scleroderma patients, and tight skin mice which develop a scleroderma-like syndrome. The epitope specificity of these antibodies has been determined using a series of fusion proteins containi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 1992-04, Vol.175 (4), p.1103-1109
Hauptverfasser:	MURYOI, T, KASTURI, K. N, KAFINA, M. J, CRAM, D. S, HARRISON, L. C, SASAKI, T, BONA, C. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - immunology Antibody Specificity Autoantibodies - immunology Autoantigens - immunology Autoimmune Diseases - immunology Biological and medical sciences Blotting, Western DNA Topoisomerases, Type I - chemistry DNA Topoisomerases, Type I - immunology Epitopes Medical sciences Mice Mice, Mutant Strains - immunology Molecular Sequence Data Recombinant Fusion Proteins - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!