Activation events during thymic selection

During their differentiation in the mouse thymus, CD4+8- cells undergo several of the sequential changes observed upon normal activation of mature, peripheral CD4+ lymphocytes. Expression of CD69, an early activation marker, is first observed on a minority of cells at the T cell receptor (TCR)lo/med...

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Veröffentlicht in:	The Journal of experimental medicine 1992-03, Vol.175 (3), p.731-742
Hauptverfasser:	BENDELAC, A, MATZINGER, P, SEDER, R. A, PAUL, W. E, SCHWARTZ, R. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences CD4 Antigens - analysis CD8 Antigens - analysis Cell Differentiation Fetus Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Interferon-gamma - metabolism Interleukin-2 - metabolism Interleukin-4 - metabolism Lectins, C-Type Lymphocyte Activation - physiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred C57BL Organ Culture Techniques Spleen - cytology T-Lymphocytes - immunology Thymus Gland - cytology Thymus Gland - embryology
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