Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the α helices and β sheets of the class I peptide binding site

A chimeric class I glycoprotein was created to investigate the functional contribution of the alpha helices and the beta-pleated sheets in forming the antigen recognition site (ARS) of antigen-presenting molecules. This novel molecule was generated by replacing the DNA sequences encoding the alpha h...

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Veröffentlicht in:	The Journal of experimental medicine 1992-03, Vol.175 (3), p.821-829
Hauptverfasser:	HUNT, H. D, MUNITZ, T. I, PEASE, L. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Antigens Base Sequence Binding Sites Biological and medical sciences Chimera - genetics Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility antigens (hla, h-2 and other systems) Histocompatibility Antigens Class I - chemistry Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Isoantigens - immunology Mice Mice, Inbred C3H Mice, Inbred C57BL Molecular immunology Molecular Sequence Data Mutation Protein Conformation T-Lymphocytes, Cytotoxic - immunology
Online-Zugang:	Volltext
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