Signal transduction by the CD2 antigen in T cells and natural killer cells : requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, FcγRIIIA (CD16)

Crosslinking of CD2 antigen on T lymphocytes and natural killer (NK) cells leads to a rise in cytoplasmic-free Ca2+ concentration ([Ca2+]i). However, CD2 seems unlikely to interact directly with the second messenger pathways since signaling via CD2 is poor in T cells that lack the T cell receptor (T...

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