Molecular interactions of complement receptors on B lymphocytes : a CR1/CR2 complex distinct from the CR2/CD19 complex
The complement system augments the humoral immune response to low concentrations of antigen. This effect may be partly mediated by complement receptors on the surface of B lymphocytes that bind immunogenic complexes bearing fragments of C3 and C4. We have shown by immunoprecipitation analysis that t...
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| Veröffentlicht in: | The Journal of experimental medicine 1991-05, Vol.173 (5), p.1083-1089 |
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| container_title | The Journal of experimental medicine |
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| creator | TUVESON, D. A AHEARN, J. M MATSUMOTO, A. K FEARON, D. T |
| description | The complement system augments the humoral immune response to low concentrations of antigen. This effect may be partly mediated by complement receptors on the surface of B lymphocytes that bind immunogenic complexes bearing fragments of C3 and C4. We have shown by immunoprecipitation analysis that the two complement receptors expressed by B lymphocytes, complement receptor 1 (CR1) and CR2, form a detergent-sensitive complex on the surface of tonsillar B lymphocytes and on K562 erythroleukemia cells that were co-transfected with cDNAs encoding CR1 and CR2. The CR1/CR2 complex is distinct from the CR2/CD19 complex and may assist B cell activation by efficiently capturing C3b-containing immunogens and maintaining such immunogens on the B cell after CR1 and factor I-mediated cleavage to iC3b and C3dg. The complement activating immunogen may then trigger signal transduction by the CR1/CR2 complex, the CR2/CD19 complex, or membrane immunoglobulin. |
| doi_str_mv | 10.1084/jem.173.5.1083 |
| format | Article |
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Psychology ; Fundamental immunology ; Humans ; Leukemia, Erythroblastic, Acute - metabolism ; Leukemia, Erythroblastic, Acute - pathology ; Leukemia, Erythroblastic, Acute - physiopathology ; Molecular immunology ; Palatine Tonsil - cytology ; Precipitin Tests ; Receptors, Complement - genetics ; Receptors, Complement - metabolism ; Receptors, Complement - physiology ; Receptors, Complement 3b ; Receptors, Complement 3d ; Signal Transduction - physiology ; Transfection - genetics</subject><ispartof>The Journal of experimental medicine, 1991-05, Vol.173 (5), p.1083-1089</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4563-e35dc88fa354015bf5a349dfcb54d485b5faa30188e849dd8ed84fe2f84a80623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19823456$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1708808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TUVESON, D. A</creatorcontrib><creatorcontrib>AHEARN, J. M</creatorcontrib><creatorcontrib>MATSUMOTO, A. K</creatorcontrib><creatorcontrib>FEARON, D. T</creatorcontrib><title>Molecular interactions of complement receptors on B lymphocytes : a CR1/CR2 complex distinct from the CR2/CD19 complex</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>The complement system augments the humoral immune response to low concentrations of antigen. This effect may be partly mediated by complement receptors on the surface of B lymphocytes that bind immunogenic complexes bearing fragments of C3 and C4. We have shown by immunoprecipitation analysis that the two complement receptors expressed by B lymphocytes, complement receptor 1 (CR1) and CR2, form a detergent-sensitive complex on the surface of tonsillar B lymphocytes and on K562 erythroleukemia cells that were co-transfected with cDNAs encoding CR1 and CR2. The CR1/CR2 complex is distinct from the CR2/CD19 complex and may assist B cell activation by efficiently capturing C3b-containing immunogens and maintaining such immunogens on the B cell after CR1 and factor I-mediated cleavage to iC3b and C3dg. The complement activating immunogen may then trigger signal transduction by the CR1/CR2 complex, the CR2/CD19 complex, or membrane immunoglobulin.</description><subject>Antigens, CD19</subject><subject>Antigens, Differentiation, B-Lymphocyte - genetics</subject><subject>Antigens, Differentiation, B-Lymphocyte - metabolism</subject><subject>Antigens, Differentiation, B-Lymphocyte - physiology</subject><subject>B-Lymphocytes - metabolism</subject><subject>B-Lymphocytes - physiology</subject><subject>B-Lymphocytes - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Complement</subject><subject>DNA - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Leukemia, Erythroblastic, Acute - metabolism</subject><subject>Leukemia, Erythroblastic, Acute - pathology</subject><subject>Leukemia, Erythroblastic, Acute - physiopathology</subject><subject>Molecular immunology</subject><subject>Palatine Tonsil - cytology</subject><subject>Precipitin Tests</subject><subject>Receptors, Complement - genetics</subject><subject>Receptors, Complement - metabolism</subject><subject>Receptors, Complement - physiology</subject><subject>Receptors, Complement 3b</subject><subject>Receptors, Complement 3d</subject><subject>Signal Transduction - physiology</subject><subject>Transfection - genetics</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS0EKqFw5YbkC9w28Wcy4YAEy0crtUKq4Gw53jHZyrtebKci_z2OEmg5cbJm3m-eZvwIecnZnDNQi1sc5nwl5_pQykdkxrVizVpLeExmjAnRcMZWT8mznG8Z40rp5Rk54ysGwGBG7q5jQLcLNtF-LJisK30cM42eujhMAQccC03ocCox1f5IP9CwH6ZtdPuCmb6llrY3fNHeiNPEL9r1ufSjK9SnONCyxUqIRfuRr_8gz8kTb0PGF6f3nHz__Olbe9Fcff1y2b6_alzdUzYodecAvJX1KK43Xlup1p13G606BXqjvbWScQCE2u8AO1AehQdlgS2FPCfvjr7TbjNg5-oxyQYzpX6waW-i7c2_ythvzY94ZwSvpopVgzcngxR_7jAXM_TZYQh2xLjLBpiWigv-X5AvmQbQuoLzI-hSzDmh_7sNZ-YQqamRmhqp0YdS1oFXD2-4x48ZVv31SbfZ2eCTHV2f77E1CHn4zd_Ndqqc</recordid><startdate>19910501</startdate><enddate>19910501</enddate><creator>TUVESON, D. A</creator><creator>AHEARN, J. M</creator><creator>MATSUMOTO, A. K</creator><creator>FEARON, D. T</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910501</creationdate><title>Molecular interactions of complement receptors on B lymphocytes : a CR1/CR2 complex distinct from the CR2/CD19 complex</title><author>TUVESON, D. A ; AHEARN, J. M ; MATSUMOTO, A. K ; FEARON, D. T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4563-e35dc88fa354015bf5a349dfcb54d485b5faa30188e849dd8ed84fe2f84a80623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Antigens, CD19</topic><topic>Antigens, Differentiation, B-Lymphocyte - genetics</topic><topic>Antigens, Differentiation, B-Lymphocyte - metabolism</topic><topic>Antigens, Differentiation, B-Lymphocyte - physiology</topic><topic>B-Lymphocytes - metabolism</topic><topic>B-Lymphocytes - physiology</topic><topic>B-Lymphocytes - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Complement</topic><topic>DNA - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Leukemia, Erythroblastic, Acute - metabolism</topic><topic>Leukemia, Erythroblastic, Acute - pathology</topic><topic>Leukemia, Erythroblastic, Acute - physiopathology</topic><topic>Molecular immunology</topic><topic>Palatine Tonsil - cytology</topic><topic>Precipitin Tests</topic><topic>Receptors, Complement - genetics</topic><topic>Receptors, Complement - metabolism</topic><topic>Receptors, Complement - physiology</topic><topic>Receptors, Complement 3b</topic><topic>Receptors, Complement 3d</topic><topic>Signal Transduction - physiology</topic><topic>Transfection - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TUVESON, D. A</creatorcontrib><creatorcontrib>AHEARN, J. M</creatorcontrib><creatorcontrib>MATSUMOTO, A. K</creatorcontrib><creatorcontrib>FEARON, D. 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T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular interactions of complement receptors on B lymphocytes : a CR1/CR2 complex distinct from the CR2/CD19 complex</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1991-05-01</date><risdate>1991</risdate><volume>173</volume><issue>5</issue><spage>1083</spage><epage>1089</epage><pages>1083-1089</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><coden>JEMEAV</coden><abstract>The complement system augments the humoral immune response to low concentrations of antigen. This effect may be partly mediated by complement receptors on the surface of B lymphocytes that bind immunogenic complexes bearing fragments of C3 and C4. We have shown by immunoprecipitation analysis that the two complement receptors expressed by B lymphocytes, complement receptor 1 (CR1) and CR2, form a detergent-sensitive complex on the surface of tonsillar B lymphocytes and on K562 erythroleukemia cells that were co-transfected with cDNAs encoding CR1 and CR2. The CR1/CR2 complex is distinct from the CR2/CD19 complex and may assist B cell activation by efficiently capturing C3b-containing immunogens and maintaining such immunogens on the B cell after CR1 and factor I-mediated cleavage to iC3b and C3dg. The complement activating immunogen may then trigger signal transduction by the CR1/CR2 complex, the CR2/CD19 complex, or membrane immunoglobulin.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><pmid>1708808</pmid><doi>10.1084/jem.173.5.1083</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antigens, CD19 Antigens, Differentiation, B-Lymphocyte - genetics Antigens, Differentiation, B-Lymphocyte - metabolism Antigens, Differentiation, B-Lymphocyte - physiology B-Lymphocytes - metabolism B-Lymphocytes - physiology B-Lymphocytes - ultrastructure Biological and medical sciences Complement DNA - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Leukemia, Erythroblastic, Acute - metabolism Leukemia, Erythroblastic, Acute - pathology Leukemia, Erythroblastic, Acute - physiopathology Molecular immunology Palatine Tonsil - cytology Precipitin Tests Receptors, Complement - genetics Receptors, Complement - metabolism Receptors, Complement - physiology Receptors, Complement 3b Receptors, Complement 3d Signal Transduction - physiology Transfection - genetics |
| title | Molecular interactions of complement receptors on B lymphocytes : a CR1/CR2 complex distinct from the CR2/CD19 complex |
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