Interleukin 10 : a novel stimulatory factor for mast cells and their progenitors
We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth...
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| Veröffentlicht in: | The Journal of experimental medicine 1991-02, Vol.173 (2), p.507-510 |
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| container_title | The Journal of experimental medicine |
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| creator | THOMPSON-SNIPES, L DHAR, V BOND, M. W MOSMANN, T. R MOORE, K. W RENNICK, D. M |
| description | We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses. |
| doi_str_mv | 10.1084/jem.173.2.507 |
| format | Article |
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This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.173.2.507</identifier><identifier>PMID: 1899106</identifier><identifier>CODEN: JEMEAV</identifier><language>eng</language><publisher>New York, NY: Rockefeller University Press</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Animals ; Biological and medical sciences ; Cell Division ; Cell Line ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunobiology ; Interleukin-10 ; Interleukin-3 - physiology ; Interleukin-4 - physiology ; Interleukins - physiology ; Lymphokines, interleukins ( function, expression) ; Mast Cells - cytology ; Mast Cells - ultrastructure ; Mice ; Mice, Inbred C57BL ; Rats ; Rats, Inbred Strains ; Recombinant Proteins ; Regulatory factors and their cellular receptors</subject><ispartof>The Journal of experimental medicine, 1991-02, Vol.173 (2), p.507-510</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-8a99bbe65250c9f92b1f5f9e13552465702de17b482761e6b3877e02823bbdd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19766231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1899106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THOMPSON-SNIPES, L</creatorcontrib><creatorcontrib>DHAR, V</creatorcontrib><creatorcontrib>BOND, M. W</creatorcontrib><creatorcontrib>MOSMANN, T. R</creatorcontrib><creatorcontrib>MOORE, K. W</creatorcontrib><creatorcontrib>RENNICK, D. M</creatorcontrib><title>Interleukin 10 : a novel stimulatory factor for mast cells and their progenitors</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Cell Line</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunobiology</subject><subject>Interleukin-10</subject><subject>Interleukin-3 - physiology</subject><subject>Interleukin-4 - physiology</subject><subject>Interleukins - physiology</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>Mast Cells - cytology</subject><subject>Mast Cells - ultrastructure</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Recombinant Proteins</subject><subject>Regulatory factors and their cellular receptors</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQRi1EVZbCkSOSL_SW7YwdOzYHJFQVqFQJDr1bTjJpXRJnsZNK_fd4tSsKJw7WHL6nT555jL1D2CKY-uKBpi02ciu2CpoXbIOqhsoqaV6yDYAQFQI0r9jrnB8AsK6VPmWnaKxF0Bv24zoulEZaf4bIEfhH7nmcH2nkeQnTOvplTk988F2ZfChv8nnhHY1j5j72fLmnkPguzXcUQ2HyG3Yy-DHT2-M8Y7dfrm4vv1U3379eX36-qbpam6Uy3tq2Ja2Egs4OVrQ4qMESSqVErVUDoids2tqIRiPpVpqmIRBGyLbte3nGPh1qd2s7Ud9RXJIf3S6FyacnN_vg_k1iuHd386MTiKXJloLzY0Gaf62UFzeFvN_LR5rX7AzUEsrB_gui3h9YyAJWB7BLc86Jhj-_QXB7Va6ockWVE66oKvz7v1d4pg9uSv7hmPvc-XFIPnYhP2O20VpIlL8BcUOcfw</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>THOMPSON-SNIPES, L</creator><creator>DHAR, V</creator><creator>BOND, M. W</creator><creator>MOSMANN, T. R</creator><creator>MOORE, K. W</creator><creator>RENNICK, D. M</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910201</creationdate><title>Interleukin 10 : a novel stimulatory factor for mast cells and their progenitors</title><author>THOMPSON-SNIPES, L ; DHAR, V ; BOND, M. W ; MOSMANN, T. R ; MOORE, K. W ; RENNICK, D. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-8a99bbe65250c9f92b1f5f9e13552465702de17b482761e6b3877e02823bbdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Cell Line</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunobiology</topic><topic>Interleukin-10</topic><topic>Interleukin-3 - physiology</topic><topic>Interleukin-4 - physiology</topic><topic>Interleukins - physiology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Mast Cells - cytology</topic><topic>Mast Cells - ultrastructure</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Recombinant Proteins</topic><topic>Regulatory factors and their cellular receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMPSON-SNIPES, L</creatorcontrib><creatorcontrib>DHAR, V</creatorcontrib><creatorcontrib>BOND, M. W</creatorcontrib><creatorcontrib>MOSMANN, T. R</creatorcontrib><creatorcontrib>MOORE, K. W</creatorcontrib><creatorcontrib>RENNICK, D. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin 10 : a novel stimulatory factor for mast cells and their progenitors</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>173</volume><issue>2</issue><spage>507</spage><epage>510</epage><pages>507-510</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><coden>JEMEAV</coden><abstract>We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><pmid>1899106</pmid><doi>10.1084/jem.173.2.507</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Cell Division Cell Line Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Interleukin-10 Interleukin-3 - physiology Interleukin-4 - physiology Interleukins - physiology Lymphokines, interleukins ( function, expression) Mast Cells - cytology Mast Cells - ultrastructure Mice Mice, Inbred C57BL Rats Rats, Inbred Strains Recombinant Proteins Regulatory factors and their cellular receptors |
| title | Interleukin 10 : a novel stimulatory factor for mast cells and their progenitors |
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