FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy for tumors dependent on deregulated NOTCH activity. To clarify the basis for GSI resistance in T cell acute lymphoblastic leukemia (T-ALL), we studied T-ALL cell lines wit...

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Veröffentlicht in:	The Journal of experimental medicine 2007-08, Vol.204 (8), p.1813-1824
Hauptverfasser:	O'Neil, Jennifer, Grim, Jonathan, Strack, Peter, Rao, Sudhir, Tibbitts, Deanne, Winter, Christopher, Hardwick, James, Welcker, Markus, Meijerink, Jules P, Pieters, Rob, Draetta, Giulio, Sears, Rosalie, Clurman, Bruce E, Look, A Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Apoptosis Cell Cycle Cell Cycle Proteins - genetics Cell Line, Tumor Enzyme Inhibitors - pharmacology F-Box Proteins - genetics F-Box-WD Repeat-Containing Protein 7 Gene Expression Regulation, Neoplastic Humans Leukemia - genetics Leukemia - metabolism Molecular Sequence Data Mutation Protein Structure, Tertiary Receptors, Notch - genetics Receptors, Notch - metabolism RNA, Messenger - metabolism Ubiquitin-Protein Ligases - genetics
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