Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification

Chondrocyte hypertrophy during endochondral ossification is a well-controlled process in which proliferating chondrocytes stop proliferating and differentiate into hypertrophic chondrocytes, which then undergo apoptosis. Chondrocyte hypertrophy induces angiogenesis and mineralization. This step is c...

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Veröffentlicht in:	The Journal of experimental medicine 2007-07, Vol.204 (7), p.1613-1623
Hauptverfasser:	Morita, Kozo, Miyamoto, Takeshi, Fujita, Nobuyuki, Kubota, Yoshiaki, Ito, Keisuke, Takubo, Keiyo, Miyamoto, Kana, Ninomiya, Ken, Suzuki, Toru, Iwasaki, Ryotaro, Yagi, Mitsuru, Takaishi, Hironari, Toyama, Yoshiaki, Suda, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Antioxidants - pharmacology Ataxia Telangiectasia Mutated Proteins Calcification, Physiologic - drug effects Calcification, Physiologic - physiology Cell Cycle Proteins - genetics Cell Differentiation - drug effects Cell Differentiation - physiology Cell Division Cell Line Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - pathology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Hypertrophy Mice Mice, Knockout Neovascularization, Physiologic - drug effects Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Reactive Oxygen Species - metabolism Reactive Oxygen Species - pharmacology Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics
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