Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

Intrarectal infection between men who have sex with men represents a predominant form of human immunodeficiency virus (HIV) transmission in developed countries. Currently there are no adequate small animal models that recapitulate intrarectal HIV transmission. Here we demonstrate that human lymphocy...

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Veröffentlicht in:	The Journal of experimental medicine 2007-04, Vol.204 (4), p.705-714
Hauptverfasser:	Sun, Zhifeng, Denton, Paul W, Estes, Jacob D, Othieno, Florence A, Wei, Bangdong L, Wege, Anja K, Melkus, Michael W, Padgett-Thomas, Angela, Zupancic, Mary, Haase, Ashley T, Garcia, J Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - immunology Bone Marrow - metabolism Brief Definitive Reports CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology Cell Proliferation HIV Infections - immunology HIV Infections - pathology HIV Infections - transmission HIV Infections - virology HIV-1 - pathogenicity HIV-1 - physiology Humans Liver - immunology Liver - metabolism Lymphoid Tissue - immunology Lymphoid Tissue - metabolism Mice Phenotype Receptors, CCR5 - metabolism Receptors, CXCR4 - metabolism Rectum - immunology Rectum - injuries Rectum - pathology Rectum - virology Thymus Gland - immunology Thymus Gland - metabolism
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