Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

B cells responding to T-dependent antigen either differentiate rapidly into extrafollicular plasma cells or enter germinal centers and undergo somatic hypermutation and affinity maturation. However, the physiological cues that direct B cell differentiation down one pathway versus the other are unkno...

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Veröffentlicht in:The Journal of experimental medicine 2006-04, Vol.203 (4), p.1081-1091
Hauptverfasser: Paus, Didrik, Phan, Tri Giang, Chan, Tyani D, Gardam, Sandra, Basten, Antony, Brink, Robert
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Sprache:eng
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