Virus-specific CD4+ T cells: ready for direct attack
CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-tra...
Gespeichert in:
| Veröffentlicht in: | The Journal of experimental medicine 2006-04, Vol.203 (4), p.805-808 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 808 |
|---|---|
| container_issue | 4 |
| container_start_page | 805 |
| container_title | The Journal of experimental medicine |
| container_volume | 203 |
| creator | Heller, Kevin N Gurer, Cagan Münz, Christian |
| description | CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4+ T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4+ T cells. |
| doi_str_mv | 10.1084/jem.20060215 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2118265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67866300</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-414fe6c94c657a52635bc987181725f7f20f20ceee4da8bc67cb6c2f1823c7933</originalsourceid><addsrcrecordid>eNpVkMtLw0AQhxdRbK3ePEtOXjR19p14EKQ-oeClel02m13dmjR1NxH635vS-oKBOcyPb2Y-hI4xjDFk7GJu6zEBEEAw30FDzBmkOafZLhoCEJJiADlABzHOATBjXOyjARac5TzPh4i9-NDFNC6t8c6bZHLDzpJZYmxVxcskWF2uEteEpPTBmjbRbavN-yHac7qK9mjbR-j57nY2eUinT_ePk-tpamhG2pRh5qwwOTOCS82JoLwweSZxhiXhTjoCfRlrLSt1VhghTSEMcTgj1Mic0hG62nCXXVHb0thFG3SllsHXOqxUo736P1n4N_XafCqCe4bgPeB0CwjNR2djq2of17_phW26qITMhKAAffB8EzShiTFY97MEg1prVr1m9a25j5_8Pew3vPVKvwCB43eS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67866300</pqid></control><display><type>article</type><title>Virus-specific CD4+ T cells: ready for direct attack</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Heller, Kevin N ; Gurer, Cagan ; Münz, Christian</creator><creatorcontrib>Heller, Kevin N ; Gurer, Cagan ; Münz, Christian</creatorcontrib><description>CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4+ T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4+ T cells.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.20060215</identifier><identifier>PMID: 16549599</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - virology ; Commentaries ; Cytotoxicity, Immunologic - immunology ; Humans ; Immunity, Cellular</subject><ispartof>The Journal of experimental medicine, 2006-04, Vol.203 (4), p.805-808</ispartof><rights>Copyright © 2006, The Rockefeller University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-414fe6c94c657a52635bc987181725f7f20f20ceee4da8bc67cb6c2f1823c7933</citedby><cites>FETCH-LOGICAL-c382t-414fe6c94c657a52635bc987181725f7f20f20ceee4da8bc67cb6c2f1823c7933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16549599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heller, Kevin N</creatorcontrib><creatorcontrib>Gurer, Cagan</creatorcontrib><creatorcontrib>Münz, Christian</creatorcontrib><title>Virus-specific CD4+ T cells: ready for direct attack</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4+ T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4+ T cells.</description><subject>Animals</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>Commentaries</subject><subject>Cytotoxicity, Immunologic - immunology</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtLw0AQhxdRbK3ePEtOXjR19p14EKQ-oeClel02m13dmjR1NxH635vS-oKBOcyPb2Y-hI4xjDFk7GJu6zEBEEAw30FDzBmkOafZLhoCEJJiADlABzHOATBjXOyjARac5TzPh4i9-NDFNC6t8c6bZHLDzpJZYmxVxcskWF2uEteEpPTBmjbRbavN-yHac7qK9mjbR-j57nY2eUinT_ePk-tpamhG2pRh5qwwOTOCS82JoLwweSZxhiXhTjoCfRlrLSt1VhghTSEMcTgj1Mic0hG62nCXXVHb0thFG3SllsHXOqxUo736P1n4N_XafCqCe4bgPeB0CwjNR2djq2of17_phW26qITMhKAAffB8EzShiTFY97MEg1prVr1m9a25j5_8Pew3vPVKvwCB43eS</recordid><startdate>20060417</startdate><enddate>20060417</enddate><creator>Heller, Kevin N</creator><creator>Gurer, Cagan</creator><creator>Münz, Christian</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060417</creationdate><title>Virus-specific CD4+ T cells: ready for direct attack</title><author>Heller, Kevin N ; Gurer, Cagan ; Münz, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-414fe6c94c657a52635bc987181725f7f20f20ceee4da8bc67cb6c2f1823c7933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>Commentaries</topic><topic>Cytotoxicity, Immunologic - immunology</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heller, Kevin N</creatorcontrib><creatorcontrib>Gurer, Cagan</creatorcontrib><creatorcontrib>Münz, Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heller, Kevin N</au><au>Gurer, Cagan</au><au>Münz, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virus-specific CD4+ T cells: ready for direct attack</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>2006-04-17</date><risdate>2006</risdate><volume>203</volume><issue>4</issue><spage>805</spage><epage>808</epage><pages>805-808</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4+ T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4+ T cells.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>16549599</pmid><doi>10.1084/jem.20060215</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 2006-04, Vol.203 (4), p.805-808 |
| issn | 0022-1007 1540-9538 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2118265 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Commentaries Cytotoxicity, Immunologic - immunology Humans Immunity, Cellular |
| title | Virus-specific CD4+ T cells: ready for direct attack |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T01%3A51%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Virus-specific%20CD4+%20T%20cells:%20ready%20for%20direct%20attack&rft.jtitle=The%20Journal%20of%20experimental%20medicine&rft.au=Heller,%20Kevin%20N&rft.date=2006-04-17&rft.volume=203&rft.issue=4&rft.spage=805&rft.epage=808&rft.pages=805-808&rft.issn=0022-1007&rft.eissn=1540-9538&rft_id=info:doi/10.1084/jem.20060215&rft_dat=%3Cproquest_pubme%3E67866300%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67866300&rft_id=info:pmid/16549599&rfr_iscdi=true |