Antiidiotypic DNA vaccination induces serum bactericidal activity and protection against group B meningococci

No vaccine is available for preventing infections by serogroup B Neisseria meningitidis (MenB), which accounts for a major portion of meningococcal cases in developed countries, because of the poor immunogenicity of the capsular polysaccharide (CP) even after protein conjugation. We have previously...

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Veröffentlicht in:	The Journal of experimental medicine 2006-01, Vol.203 (1), p.111-118
Hauptverfasser:	Beninati, Concetta, Midiri, Angelina, Mancuso, Giuseppe, Biondo, Carmelo, Arigò, Milena, Gerace, Elisabetta, Papasergi, Salvatore, Gambuzza, Maria, Boretti, Mauro, Magliani, Walter, Conti, Stefania, Polonelli, Luciano, Teti, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antibodies, Bacterial - immunology Bacterial Vaccines Blood Bactericidal Activity Cercopithecus aethiops COS Cells Immunoglobulin Variable Region - immunology Meningococcal Infections - immunology Meningococcal Infections - prevention & control Mice Mice, Inbred BALB C Neisseria meningitidis Neisseria meningitidis, Serogroup B - immunology Neisseria meningitidis, Serogroup B - pathogenicity Rats Rats, Wistar Vaccines, DNA
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