Two Drosophila Beta Tubulin Isoforms Are Not Functionally Equivalent

We have tested the functional capacity of different beta tubulin isoforms in vivo by expressing β3-tubulin either in place of or in addition to β2-tubulin in the male germ line of Drosophila melanogaster. The testes-specific isoform, β2, is conserved relative to major metazoan beta tubulins, while t...

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Veröffentlicht in:	The Journal of cell biology 1990-09, Vol.111 (3), p.1009-1026
Hauptverfasser:	Hoyle, Henry D., Raff, Elizabeth C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Contractile proteins Diptera Drosophila Drosophila melanogaster Drosophila melanogaster - physiology Drosophilidae Fertility - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Germ cells Holoproteins Hybridity Isotypes Male Male animals Meiosis Microtubules Microtubules - metabolism Multigene Family Protein isoforms Proteins Recombinant Fusion Proteins - metabolism Spermatids Spermatids - cytology Spermatids - metabolism Spermatogenesis - physiology Spermatozoa Spindle Apparatus - metabolism Testes Transfection Tubulin - genetics Tubulin - physiology
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