Immunocytochemical Localization of Mutant Low Density Lipoprotein Receptors That Fail to Reach the Golgi Complex

In the low density lipoprotein (LDL) receptor system, blocks in intracellular movement of a cell surface receptor result from naturally occurring mutations. These mutations occur in patients with familial hypercholesterolemia. One class of mutant LDL receptor genes (class 2 mutations) produces a rec...

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Veröffentlicht in:	The Journal of cell biology 1988-06, Vol.106 (6), p.1831-1841
Hauptverfasser:	Pathak, Ravindra K., Merkle, Roberta K., Cummings, Richard D., Goldstein, Joseph L., Brown, Michael S., Richard G. W. Anderson
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Compartmentation Cell receptors Cell structures and functions Cell surface receptors Cells Coated Pits, Cell-Membrane - metabolism DNA Mutational Analysis Endoplasmic Reticulum - metabolism Endosomes Endosomes - metabolism Fibroblasts Fundamental and applied biological sciences. Psychology Golgi apparatus Golgi Apparatus - metabolism Humans Hyperlipoproteinemia Type II - genetics Immunohistochemistry Intracellular Membranes - metabolism LDL receptors Lipoproteins, LDL - metabolism Microscopy, Electron Molecular and cellular biology Multivesicular bodies Protein Processing, Post-Translational Reaction products Receptors Receptors, LDL - genetics Receptors, LDL - metabolism Sugars
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