Differentiation-Related Expression of a Major 64K Corneal Keratin in vivo and in Culture Suggests Limbal Location of Corneal Epithelial Stem Cells

In this paper we present keratin expression data that lend strong support to a model of corneal epithelial maturation in which the stem cells are located in the limbus, the transitional zone between cornea and conjunctiva. Using a new monoclonal antibody, AE5, which is highly specific for a 64,000-m...

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Veröffentlicht in:	The Journal of cell biology 1986-07, Vol.103 (1), p.49-62
Hauptverfasser:	Schermer, Alexander, Galvin, Sharon, Sun, Tung-Tien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal Biological and medical sciences Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Movement Cell physiology Cells Cells, Cultured Cornea Cornea - cytology Cultured cells Epithelial Cells Epithelium Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Isoelectric Point Keratinocytes Keratins Keratins - genetics Keratins - immunology Keratins - metabolism Mitosis Molecular and cellular biology Molecular Weight Rabbits Stem cells Stem Cells - cytology
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