Platelet-Collagen Adhesion: Inhibition by a Monoclonal Antibody That Binds Glycoprotein IIb

To identify platelet surface structures involved in adhesion to collagen, the effect of 16 murine antiplatelet membrane hybridoma antibodies were tested in a defined, in vitro assay. Four of these antibodies inhibited platelet-collagen adhesion and reacted with a polypeptide with Mr ∼ 125,000, as de...

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Veröffentlicht in:	The Journal of cell biology 1984-12, Vol.99 (6), p.2056-2060
Hauptverfasser:	Shadle, Paula J., Ginsberg, Mark H., Plow, Edward F., Barondes, Samuel H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Antibodies Antibodies, Monoclonal Antigen-Antibody Complex Antigens Antiserum Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - physiology Chromatography, Affinity Collagen Collagens Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Gels Glycoproteins Glycoproteins - analysis Humans Hybridomas Membrane Proteins - analysis Molecular and cellular biology Molecular Weight Monoclonal antibodies Platelet Platelet Aggregation Platelet Membrane Glycoproteins Platelets Radioimmunoassay
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