Gene Amplification-Associated Cytogenetic Aberrations and Protein Changes in Vincristine-Resistant Chinese Hamster, Mouse, and Human Cells

We carried out cytogenetic studies of four Chinese hamster, mouse, and human cell lines selected for high levels of resistance (500- to 4,000-fold) to vincristine (VCR) by a multistep selection procedure. All cells examined contained gene amplification-associated metaphase chromosome abnormalities,...

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Veröffentlicht in:	The Journal of cell biology 1985-02, Vol.100 (2), p.588-597
Hauptverfasser:	Meyers, Marian B., Spengler, Barbara A., Chang, Tien-Ding, Melera, Peter W., Biedler, June L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycin Animals Biological and medical sciences Cell Line Cell lines Cells Chromosome Aberrations Chromosomes Cricetinae Cricetulus Cross resistance Drug Resistance Fundamental and applied biological sciences. Psychology Gels Gene Amplification Genes Genic rearrangement. Recombination. Transposable element Humans Isoelectric Point Messenger RNA Mice Molecular and cellular biology Molecular genetics Molecular Weight Neurons Vincristine - toxicity
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