PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

The arginine methyltransferase PRMT6 (protein arginine methyltransferase 6) has been shown recently to regulate DNA repair and gene expression. As arginine methylation of histones is an important mechanism in transcriptional regulation, we asked whether PRMT6 possesses activity toward histones. We s...

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Veröffentlicht in:	Genes & development 2007-12, Vol.21 (24), p.3369-3380
Hauptverfasser:	Hyllus, Dawin, Stein, Claudia, Schnabel, Kristin, Schiltz, Emile, Imhof, Axel, Dou, Yali, Hsieh, James, Bauer, Uta-Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Catalysis Cell Line DNA Primers Histones - metabolism Humans Methylation Nuclear Proteins - metabolism Protein Binding Protein-Arginine N-Methyltransferases - metabolism Research Paper Transcription, Genetic
Online-Zugang:	Volltext
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