Ageing, smoking and oxidative stress
The authors claim that, for the first time, the oxidation of albumin-the most abundant protein in the BAL fluid-has been shown to account for the excessive total protein carbonylation. [...]the possibility that lung antioxidant defences might be overwhelmed is considered but further studies are nece...
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| Veröffentlicht in: | Thorax 2006-06, Vol.61 (6), p.461-462 |
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| container_title | Thorax |
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| creator | Donohue, J F |
| description | The authors claim that, for the first time, the oxidation of albumin-the most abundant protein in the BAL fluid-has been shown to account for the excessive total protein carbonylation. [...]the possibility that lung antioxidant defences might be overwhelmed is considered but further studies are necessary. Ageing plus smoking is necessary, as younger current smokers have demonstrated lower levels of oxidative stress. Since the oxidant/antioxidant imbalance is implicated in the pathogenesis of emphysema, the lack of an effect of emphysema in this study is surprising. |
| doi_str_mv | 10.1136/thx.2005.053058 |
| format | Article |
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[...]the possibility that lung antioxidant defences might be overwhelmed is considered but further studies are necessary. Ageing plus smoking is necessary, as younger current smokers have demonstrated lower levels of oxidative stress. Since the oxidant/antioxidant imbalance is implicated in the pathogenesis of emphysema, the lack of an effect of emphysema in this study is surprising.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.2005.053058</identifier><identifier>PMID: 16738041</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Age ; Aged ; ageing ; Aging ; Aging - physiology ; antioxidant ; Antioxidants ; bronchoalveolar lavage ; Chronic obstructive pulmonary disease ; Cigarettes ; Cytokines ; Enzymes ; Forced Expiratory Volume - physiology ; glutathione ; Glutathione - blood ; Heart attacks ; Humans ; Inflammation ; Long term ; Lung diseases ; Lungs ; Mortality ; Neutrophils ; Oxidation ; Oxidative stress ; Oxidative Stress - physiology ; Pathogenesis ; Pollutants ; protein carbonyls ; Proteins ; Pulmonary Disease, Chronic Obstructive - metabolism ; smoking ; Smoking - blood ; Smoking - metabolism ; Smoking - physiopathology ; Smoking cessation</subject><ispartof>Thorax, 2006-06, Vol.61 (6), p.461-462</ispartof><rights>Copyright 2006 Thorax</rights><rights>Copyright: 2006 Copyright 2006 Thorax</rights><rights>Copyright © 2006 BMJ Publishing Group and British Thoracic Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b492t-663d76245767f0d8348432143a0d7f6c469e935efaa0cda8d8a692830f80c9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://thorax.bmj.com/content/61/6/461.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://thorax.bmj.com/content/61/6/461.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,723,776,780,881,3183,23550,27901,27902,53766,53768,77343,77374</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16738041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donohue, J F</creatorcontrib><title>Ageing, smoking and oxidative stress</title><title>Thorax</title><addtitle>Thorax</addtitle><description>The authors claim that, for the first time, the oxidation of albumin-the most abundant protein in the BAL fluid-has been shown to account for the excessive total protein carbonylation. [...]the possibility that lung antioxidant defences might be overwhelmed is considered but further studies are necessary. Ageing plus smoking is necessary, as younger current smokers have demonstrated lower levels of oxidative stress. Since the oxidant/antioxidant imbalance is implicated in the pathogenesis of emphysema, the lack of an effect of emphysema in this study is surprising.</description><subject>Age</subject><subject>Aged</subject><subject>ageing</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>antioxidant</subject><subject>Antioxidants</subject><subject>bronchoalveolar lavage</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarettes</subject><subject>Cytokines</subject><subject>Enzymes</subject><subject>Forced Expiratory Volume - physiology</subject><subject>glutathione</subject><subject>Glutathione - blood</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Long term</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Pathogenesis</subject><subject>Pollutants</subject><subject>protein carbonyls</subject><subject>Proteins</subject><subject>Pulmonary Disease, Chronic Obstructive - metabolism</subject><subject>smoking</subject><subject>Smoking - blood</subject><subject>Smoking - metabolism</subject><subject>Smoking - physiopathology</subject><subject>Smoking cessation</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkNFr2zAQh0VZWbNsz3sbgY09lDq9k-ST_DIoYWsLIYUR1keh2HLqNLZbySnpf18Vh3TtS590cN_9dPcx9hVhjCjotLvZjjlAOoZUQKoP2AAl6UTwjD6wAYCEhISiI_YphBUAaET1kR0hKaFB4oD9OFu6qlmejELd3sZiZJti1G6rwnbVgxuFzrsQPrPD0q6D-7J7h2z-5_d8cpFMr84vJ2fTZCEz3iVEolDEZapIlVBoIbUUHKWwUKiSckmZy0TqSmshL6wutKWMawGlhjwrxZD96mPvNovaFblrOm_X5s5XtfWPprWVed1pqhuzbB8MR0TOMQb83AX49n7jQmfqKuRuvbaNazfBkAYBgnQEv78BV-3GN_E2g0qjItRaROq0p3LfhuBduV8FwTzrN1G_edZvev1x4tv_F7zwO98RSHqgCp3b7vvW35qIqNTM_k3MlK5nf2fXYOaRP-75Rb169_cnp7SbdA</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Donohue, J F</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200606</creationdate><title>Ageing, smoking and oxidative stress</title><author>Donohue, J F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b492t-663d76245767f0d8348432143a0d7f6c469e935efaa0cda8d8a692830f80c9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Age</topic><topic>Aged</topic><topic>ageing</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>antioxidant</topic><topic>Antioxidants</topic><topic>bronchoalveolar lavage</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cigarettes</topic><topic>Cytokines</topic><topic>Enzymes</topic><topic>Forced Expiratory Volume - physiology</topic><topic>glutathione</topic><topic>Glutathione - blood</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Long term</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Mortality</topic><topic>Neutrophils</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Pathogenesis</topic><topic>Pollutants</topic><topic>protein carbonyls</topic><topic>Proteins</topic><topic>Pulmonary Disease, Chronic Obstructive - metabolism</topic><topic>smoking</topic><topic>Smoking - blood</topic><topic>Smoking - metabolism</topic><topic>Smoking - physiopathology</topic><topic>Smoking cessation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donohue, J F</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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| source | MEDLINE; BMJ Journals - NESLi2; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Age Aged ageing Aging Aging - physiology antioxidant Antioxidants bronchoalveolar lavage Chronic obstructive pulmonary disease Cigarettes Cytokines Enzymes Forced Expiratory Volume - physiology glutathione Glutathione - blood Heart attacks Humans Inflammation Long term Lung diseases Lungs Mortality Neutrophils Oxidation Oxidative stress Oxidative Stress - physiology Pathogenesis Pollutants protein carbonyls Proteins Pulmonary Disease, Chronic Obstructive - metabolism smoking Smoking - blood Smoking - metabolism Smoking - physiopathology Smoking cessation |
| title | Ageing, smoking and oxidative stress |
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