Dissociation of Intracellular Lysosomal Rupture from the Cell Death Caused by Silica

The relationship between intracellular lysosomal rupture and cell death caused by silica was studied in P388D1macrophages. After 3 h of exposure to 150 μg silica in medium containing 1.8 mM Ca2+, 60% of the cells were unable to exclude trypan blue. In the absence of extracellular Ca2+, however, all...

Ausführliche Beschreibung